Фармакокинетика, побочные эффекты, лекарственные формы, лекарственные взаимодействия куркумина

В данном обзоре представлены современные данные о фармакокинетике, побочных эффектах, лекарственных формах и взаимодействиях куркумина. Куркумин, основной биоактивный компонент куркумы, обладает низкой биодоступностью, что обусловлено его низкой растворимостью в воде, быстрым метаболизмом в печени и быстрым выведением из организма. Описаны основные пути метаболизма куркумина, включающие его восстановление и последующее конъюгирование с глюкуроновой кислотой и сульфатами. Рассмотрены побочные эффекты куркумина, такие как гипероксалурия, железодефицитная анемия, гепатотоксичность, аритмии, аллергические реакции и потенциальные канцерогенные свойства. Обсуждаются различные лекарственные формы куркумина, разработанные для повышения его биодоступности, включая липосомы, наночастицы, гидрогели и фитосомы. Особое внимание уделено лекарственным взаимодействиям куркумина с химиотерапевтическими агентами, такими как 5-фторурацил, винкристин, гемцитабин, адриамицин и цисплатин, а также с гиполипидемическими средствами, антиагрегантами и антикоагулянтами. Представленные данные подчеркивают необходимость дальнейших исследований для оптимизации терапевтического использования куркумина и минимизации его побочных эффектов.

куркумин, фармакокинетика, лекарственные формы, лекарственные взаимодействия, побочные эффекты

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