nogrЭкспериментальная и клиническая гастроэнтерологияExperimental and Clinical Gastroenterology1682-8658«Global Media Technologies»10.31146/1682-8658-ecg-229-9-147-160nogr-2896Research ArticleКЛИНИЧЕСКАЯ ГАСТРОЭНТЕРОЛОГИЯCLINICAL GASTROENTEROLOGYФармакокинетика, побочные эффекты, лекарственные формы, лекарственные взаимодействия куркуминаPharmacokinetics, side effects, dosage forms, drug interactions of curcu-minehttps://orcid.org/0000-0003-3606-4068ШрайнерЕ. В.ShraynerE. V.noemail@neicon.ruhttps://orcid.org/0000-0001-8364-6066НиколайчукК. М.NikolaychukK. M.noemail@neicon.ruhttps://orcid.org/0000-0002-5906-4223ХвостовМ. В.KhvostovM. V.noemail@neicon.ruhttps://orcid.org/0000-0001-5881-9236ПавловаА. В.PavlovaA. V.noemail@neicon.ruhttps://orcid.org/0000-0002-3750-2958ТолстиковаТ. Г.TolstikovaT. G.noemail@neicon.ruhttps://orcid.org/0009-0002-9228-2350ВеременкоА. С.VeremenkoA. S.noemail@neicon.ruhttps://orcid.org/0009-0002-7317-6077ЛевченкоИ. Д.LevchenkoI. D.noemail@neicon.ruhttps://orcid.org/0009-0004-1880-9585ПлатоноваП. Я.PlatonovaP. Ya.noemail@neicon.ruhttps://orcid.org/0009-0008-7479-8277НовиковаМ. Ф.NovikovaM. F.noemail@neicon.ruhttps://orcid.org/0009-0004-1138-6049ТумасА. С.TumasA. S.noemail@neicon.ruhttps://orcid.org/0009-0003-0793-4236ВергуноваЕ. Е.VergunovaE. E.noemail@neicon.ruhttps://orcid.org/0009-0000-5888-0651ЛукичевД. А.LukichevD. A.noemail@neicon.ruhttps://orcid.org/0009-0007-9699-233XСергеевД. А.SergeevD. A.noemail@neicon.ruhttps://orcid.org/0000-0001-7308-7280ХавкинА. И.KhavkinA. I.khavkin@nikid.ruhttps://orcid.org/0000-0002-9494-4234ПокушаловЕ. А.PokushalovE. A.noemail@neicon.ruКудлайД. А.KudlaiD. A.noemail@neicon.ruФедеральное государственное автономное образовательное учреждение высшего образования «Новосибирский национальный исследовательский государственный университет»; Научно-исследовательский институт «Институт химической биологии и фундаментальной медицины Сибирского отделения Российской академии наук»; Общество с ограниченной ответственностью «Центр новых медицинских технологий»; Общество с ограниченной ответственностью «ЭС.ЛАБ ФАРМ» («Soloways»)РоссияNovosibirsk National Research State University; Institute of Chemical Biology and Fundamental Medicine of the Siberian Branch of the Russian Academy of Sciences; Center for New Medical Technologies; S.LAB PHARM (Soloways)Russian FederationФедеральное государственное автономное образовательное учреждение высшего образования «Новосибирский национальный исследовательский государственный университет»; Федеральное государственное бюджетное учреждение науки Новосибирский институт органической химии им. Н.Н. Ворожцова Сибирского отделения Российской академии наукРоссияNovosibirsk National Research State University; N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of SciencesRussian FederationФедеральное государственное бюджетное учреждение науки Новосибирский институт органической химии им. Н.Н. Ворожцова Сибирского отделения Российской академии наукРоссияN.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of SciencesRussian FederationФедеральное государственное автономное образовательное учреждение высшего образования «Новосибирский национальный исследовательский государственный университет»РоссияNovosibirsk National Research State UniversityRussian FederationНаучно-исследовательский клинический институт детства Министерства здравоохранения Московской области; Национальный исследовательский университет «Белгородский государственный университет»РоссияResearch and Clinical Institute of Childhood, Ministry of Health of the Moscow Region; National Research University “Belgorod State University”Russian FederationОбщество с ограниченной ответственностью «Центр новых медицинских технологий»; Общество с ограниченной ответственностью «ЭС.ЛАБ ФАРМ» («Soloways»)РоссияCenter for New Medical Technologies; S.LAB PHARM (Soloways)Russian FederationФедеральное государственное автономное образовательное учреждение высшего образования «Новосибирский национальный исследовательский государственный университет»; Федеральное государственное автономное образовательное учреждение высшего образования Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации; Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования «Московский государственный университет имени М.В. Ломоносова»РоссияNovosibirsk National Research State University; Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation, Institute of Pharmacy; Lomonosov Moscow State UniversityRussian Federation20240603202509147160Copyright © Шрайнер Е.В., Николайчук К.М., Хвостов М.В., Павлова А.В., Толстикова Т.Г., Веременко А.С., Левченко И.Д., Платонова П.Я., Новикова М.Ф., Тумас А.С., Вергунова Е.Е., Лукичев Д.А., Сергеев Д.А., Хавкин А.И., Покушалов Е.А., Кудлай Д.А., 20252025Шрайнер Е.В., Николайчук К.М., Хвостов М.В., Павлова А.В., Толстикова Т.Г., Веременко А.С., Левченко И.Д., Платонова П.Я., Новикова М.Ф., Тумас А.С., Вергунова Е.Е., Лукичев Д.А., Сергеев Д.А., Хавкин А.И., Покушалов Е.А., Кудлай Д.А.Shrayner E.V., Nikolaychuk K.M., Khvostov M.V., Pavlova A.V., Tolstikova T.G., Veremenko A.S., Levchenko I.D., Platonova P.Y., Novikova M.F., Tumas A.S., Vergunova E.E., Lukichev D.A., Sergeev D.A., Khavkin A.I., Pokushalov E.A., Kudlai D.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nogr.org/jour/article/view/2896

В данном обзоре представлены современные данные о фармакокинетике, побочных эффектах, лекарственных формах и взаимодействиях куркумина. Куркумин, основной биоактивный компонент куркумы, обладает низкой биодоступностью, что обусловлено его низкой растворимостью в воде, быстрым метаболизмом в печени и быстрым выведением из организма. Описаны основные пути метаболизма куркумина, включающие его восстановление и последующее конъюгирование с глюкуроновой кислотой и сульфатами. Рассмотрены побочные эффекты куркумина, такие как гипероксалурия, железодефицитная анемия, гепатотоксичность, аритмии, аллергические реакции и потенциальные канцерогенные свойства. Обсуждаются различные лекарственные формы куркумина, разработанные для повышения его биодоступности, включая липосомы, наночастицы, гидрогели и фитосомы. Особое внимание уделено лекарственным взаимодействиям куркумина с химиотерапевтическими агентами, такими как 5-фторурацил, винкристин, гемцитабин, адриамицин и цисплатин, а также с гиполипидемическими средствами, антиагрегантами и антикоагулянтами. Представленные данные подчеркивают необходимость дальнейших исследований для оптимизации терапевтического использования куркумина и минимизации его побочных эффектов.

This review presents current data on the pharmacokinetics, side effects, dosage forms and interactions of curcumin. Curcumin, the major bioactive component of turmeric, has low bioavailability due to its low water solubility, rapid metabolism in the liver and rapid excretion from the body. The main pathways of curcumin metabolism are described, including its reduction and subsequent conjugation with glucuronic acid and sulphates. Side effects of curcumin such as hyperoxaluria, iron deficiency anaemia, hepatotoxicity, arrhythmias, allergic reactions and potential carcinogenic properties are discussed. Various dosage forms of curcumin developed to enhance its bioavailability are discussed, including liposomes, nanoparticles, hydrogels and phytosomes. Particular attention is given to the drug interactions of curcumin with chemotherapeutic agents such as 5-fluorouracil, vincristine, gemcitabine, adriamycin and cisplatin, as well as with hypolipidaemic agents, antiaggregants and anticoagulants. These data highlight the need for further studies to optimise the therapeutic use of curcumin and minimise its side effects.

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The authors declare that there are no conflicts of interest present.