Liver and biliary system condition in children with type I diabetes mellitus depending on the duration of the disease

The aim was to assess the functional state of the liver and biliary tract in children with diabetes mellitus type I and their correlation with the duration of the disease and the severity of metabolic changes. Materials and methods. There were examined 74 patients with diabetes mellitus type I aged from 7 to 17 years. There were formed 2 groups: 1 group - children with a disease duration up to 5 years (33 people), 2 group - with a disease duration of more than 5 years (41 people). There were studied the functional state of the hepato-biliary system on the basis of clinical, laboratory and instrumental parameters. Results. With an increase in the duration of the disease, increased the number of patients with a change in the echogenicity and homogeneity of the liver parenchyma: an increase in liver echogenicity was detected in group 1 in 24.2% of cases, in group 2 - in 36.6% (p<0.05). The fatty liver index characteristic of non-alcoholic fatty liver disease were more often detected when the disease lasted more than 5 years - 17.1% versus 6.1% (p<0.05). Biochemical parameters of patients remained within the normal range with the exception of alkaline phosphatase (AP) and gamma-glutamyl transpeptidase (GGTP), significantly increasing with a duration of diabetes more than 5 years (433.91±205.01 and 411.05±220.32 U/l; 16.22±7.07 and 9.74±3.56 U/l).

дети, сахарный диабет I типа, индекс стеатоза печени, неалкогольная жировая болезнь печени, children, diabetes mellitus type I, fatty liver index, non-alcoholic fatty liver disease