The role of parasitic invasions in the genesis of inflammatory diseases of biliary tract in children

Abstract

The article presents a review of the literature on the etiopathogenesis, diagnosis and treatment of parasitic invasions in children. The etiological structure of parasites infecting the biliary system, their development cycles and places of the most frequent parasitism in the external environment are described. It is convincingly shown that Giardia has nothing to do with the gallbladder and the biliary tract. It is noted that the most frequent pathogens of parasitic invasions of the biliary tract in children are opisthorchiasis, clonorchosis and fascioliasis. The role of parasitic invasions in the formation of gallstones is shown. At the same time, the key pathogenetic mechanisms of stone formation in cholelithiasis on the background of parasitic invasion is the activation of cholesterol and pigment lithogenesis, the deconjugation of direct bilirubin in bile. It is shown that the main in the treatment of parasitic invasions is the use of etiotropic therapy (deworming). Based on a detailed analysis of modern literature, therapeutic tactics algorithms have been developed.