<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nogr</journal-id><journal-title-group><journal-title xml:lang="ru">Экспериментальная и клиническая гастроэнтерология</journal-title><trans-title-group xml:lang="en"><trans-title>Experimental and Clinical Gastroenterology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-8658</issn><publisher><publisher-name>«Global Media Technologies»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31146/1682-8658-ecg-161-1-129-136</article-id><article-id custom-type="elpub" pub-id-type="custom">nogr-736</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОР</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW</subject></subj-group></article-categories><title-group><article-title>Роль паразитарных инвазий в генезе воспалительных заболеваний билиарного тракта у детей</article-title><trans-title-group xml:lang="en"><trans-title>The role of parasitic invasions in the genesis of inflammatory diseases of biliary tract in children</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Харитонова</surname><given-names>Л. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kharitonova</surname><given-names>L. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кучеря</surname><given-names>Т. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kucherya</surname><given-names>T. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бостанджян</surname><given-names>В. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Bostanjyan</surname><given-names>V. R.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Веселова</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Veselova</surname><given-names>E. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Маталаева</surname><given-names>С. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Matalaeva</surname><given-names>S. Yu.</given-names></name></name-alternatives><email xlink:type="simple">luludi@inbox.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н. И. Пирогова Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>FDO FGBOU IN “Russian Research Medical University. Pirogov” of Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБОУ ВО Кубанский государственный медицинский университет Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal State Budgetary Educational Institution of Higher Education Kuban State Medical University of the Ministry of Health of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>20</day><month>01</month><year>2019</year></pub-date><volume>0</volume><issue>1</issue><fpage>129</fpage><lpage>136</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Харитонова Л.А., Кучеря Т.В., Бостанджян В.Р., Веселова Е.А., Маталаева С.Ю., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Харитонова Л.А., Кучеря Т.В., Бостанджян В.Р., Веселова Е.А., Маталаева С.Ю.</copyright-holder><copyright-holder xml:lang="en">Kharitonova L.A., Kucherya T.V., Bostanjyan V.R., Veselova E.A., Matalaeva S.Y.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.nogr.org/jour/article/view/736">https://www.nogr.org/jour/article/view/736</self-uri><abstract><p>В статье представлен обзор литературы по этиопатогенезу, диагностике и лечению паразитарных инвазий у детей. Представлена этиологическая структура паразитов, поражающих желчевыводящую систему, описаны их циклы развития и места наиболее частого паразитирования во внешней среде. Убедительно показано, что лямблии не имеют ничего общего с желчным пузырем и билиарным трактом в целом. Отмечено, что наиболее частыми возбудителями паразитарных инвазий билиарного тракта у детей являются описторхоз, клонорхоз и фасциолез. Показана роль паразитарных инвазий в образовании желчных камней. При этом, ключевыми патогенетическими механизмами камнеобразования при желчнокаменной болезни на фоне паразитарной инвазии является активация холестеринового и пигментного литогенеза, деконьюгация прямого билирубина в желчи. Показано, что основным в лечении паразитарных инвазий является применение этиотропной терапии (дегельминтизация). На основании детального анализа современной литературы, разработаны алгоритмы терапевтической тактики.</p></abstract><trans-abstract xml:lang="en"><p>The article presents a review of the literature on the etiopathogenesis, diagnosis and treatment of parasitic invasions in children. The etiological structure of parasites infecting the biliary system, their development cycles and places of the most frequent parasitism in the external environment are described. It is convincingly shown that Giardia has nothing to do with the gallbladder and the biliary tract. It is noted that the most frequent pathogens of parasitic invasions of the biliary tract in children are opisthorchiasis, clonorchosis and fascioliasis. The role of parasitic invasions in the formation of gallstones is shown. At the same time, the key pathogenetic mechanisms of stone formation in cholelithiasis on the background of parasitic invasion is the activation of cholesterol and pigment lithogenesis, the deconjugation of direct bilirubin in bile. It is shown that the main in the treatment of parasitic invasions is the use of etiotropic therapy (deworming). Based on a detailed analysis of modern literature, therapeutic tactics algorithms have been developed.</p></trans-abstract></article-meta></front><back><ref-list><title>References</title></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
