THE EFFECTIVENESS OF PSYLLIUM AND LACTULOSE IN TREATMENT OF FUNCTIONAL CONSTIPATION WHEN COMBINED WITH NONALCOHOLIC STEATOHEPATITIS

The aim of the study was to Evaluate the effectiveness of long-term therapy dietary fiber (DF) or lactulose on the course of functional constipation when combined with nonalcoholic steatohepatitis (NASH) Material and methods. Was conducted an open prospective comparative study in parallel groups with the inclusion of 102 patients with NASH, among whom were allocated to patients with symptoms of functional constipation. The main group consisted of 70 people (NASH and functional constipation), a comparison group of 32 people with just NASH. The main group patients were randomized into two equal subgroups of 30 people IA and IB, differentiated by the treatment of functional constipation: patients of subgroup IA in addition to modification of lifestyle was prescribed the drug lactulose, patients IB - preparation of dietary fiber (psyllium). All patients 1 time per 3 months was carried out dynamic assessment of specific markers of functional constipation, frequency of defecation, stool type, indicators of quality of life, check bacterial overgrowth syndrome. The observation period of the patients was 6 months. Results. For the period 6-month observation the most significant regression of markers of functional constipation (natureline, frequency of defecation), better tolerance of therapy, including less pronounced side effects significantly greater reduction of bacterial overgrowth syndrome (p < 0.05) was achieved only in the subgroup of dietary fiber, which is reflected in a statistically more significant improvement in quality of life than in the subgroup of lactulose. Conclusion: long-term treatment of functional constipation with psyllium is characterized by a more pronounced laxative effect, better tolerated, reduces the severity bacterial overgrowth syndrome that regularly impact on improving the quality of life compared with lactulose.

comorbid pathology, functional constipation, non-alcoholic steatohepatitis, treatment, psyllium, lactulose

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