CARDIAC DYSFUNCTION IN ALCOHOLIC LIVER CIRRHOSIS
Abstract
Objective: To evaluate structural and functional cardiac changes in patients with alcoholic cirrhosis in relation to the severity of liver disease. Methods: Study included 80 patients with alcoholic liver cirrhosis (LC) without history of cardiovascular and respiratory disease. ECG, echocardiography were performed. Plasma values of NT-proBNP were evaluated in 60 patients. Results: Left ventricular ejection fraction was normal in all patients (mean value 65,3 ± 5,8%). Left ventricular hypertrophy (LVH) (LVMI 149,8 ± 20 g/m 2) and LV diastolic dysfunction were observed in 33 (40,7%) and 58 (71,6%) patients, respectively. Median NT-proBNP value was 621,5 pg/ml (min 33 pg/ml; max 3849 pg/ml), NT-proBNP elevation (> 125 pg/ml) was observed in 47 (58%) patients. NT-proBNP level positively correlated with the number of points on the Child-Pugh score (R =0,27, p < 0,05). There was no relationship between the severity of cirrhosis and structural and functional cardiac changes. Conclusion: Patients with alcoholic LC frequently demostrate structural and functional cardiac changes such as left ventricular hypertrophy, diastolic dysfunction. NT-proBNP elevation was observed in more than half of the patients and directly correlated with the severity of cirrhosis.
About the Authors
A. S. Ivanov
“Peoples Friendship University of Russia”
Russian Federation
Russian Federation
V. A. Romanova
“Peoples Friendship University of Russia”
Russian Federation
Russian Federation
I. A. Kolesnikova
“Peoples Friendship University of Russia”
Russian Federation
Russian Federation
O. S. Arisheva
“Peoples Friendship University of Russia”
Russian Federation
Russian Federation
I. V. Garmash
“Peoples Friendship University of Russia”
Russian Federation
Russian Federation
Z. D. Kobalava
“Peoples Friendship University of Russia”
Russian Federation
Russian Federation
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Review
For citations:
Ivanov A.S., Romanova V.A., Kolesnikova I.A., Arisheva O.S., Garmash I.V., Kobalava Z.D. CARDIAC DYSFUNCTION IN ALCOHOLIC LIVER CIRRHOSIS. Experimental and Clinical Gastroenterology. 2018;(6):52-57. (In Russ.)
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