EFFECTIVENESS OF THE EFFECTS OF ERADICATION THERAPY ON THE CONTENT OF PROINFLAMMATORY CYTOKINES IN GASTRIC JUICE IN PATIENTS WITH CHRONIC GASTRODUODENAL DISEASES ASSOCIATED WITH Helicobacter pylori

Abstract

The aim of research was to evaluate the effectiveness of the effect of eradication therapy on the cytokine status of gastric juice in patients with chronic non-atrophic gastritis (HNG) and duodenal ulcer (duodenal ulcer) associated with Helicobacter pylori. Materials and methods. Clinical observations and laboratory-instrumental studies were performed in 95 patients aged 20 to 55 years with HNG and duodenal ulcer with determination of cytokine content of IL-1β, IL-6 and TNF-α in the fasting portion of gastric juice. Results. The most pronounced decrease in the content of proinflammatory cytokines in gastric juice on the background of treatment was found in patients of the 1st group who received combined therapy according to the scheme omeprazole + + clarithromycin + amoxicillin. Analysis of the content of proinflammatory cytokines (IL-1β, IL-6 and TNF-α) in gastric juice in patients with acute exacerbation showed that their concentration in all 8 patients after the course of therapy exceeded the norm (P <0.05) and was IL -1β - 30,30 + 1,15 pg / l, IL-6-10,4 + 0,83 pg / l and TNF-α - 32,5 + 1,13 pg / l. At the same time, the level of proinflammatory cytokines in gastric juice correlated with the degree of dissemination of H. pylori in the mucosa of the gastroduodenal zone. Conclusion. Helicobacter pylori infection in inflammation and ulceration in the mucous membrane of the stomach and duodenum, possibly in addition to other mechanisms, affects the activation of pro-inflammatory cytokines (IL-1beta, IL-6, TNF-alpha) in gastric juice. Incomplete eradication of H. pylori after treatment during clinical endoscopic remission in patients with duodenal ulcer in the vast majority of cases is accompanied by the preservation of an increased level of pro-inflammatory cytokines in gastric juice, which may be one of the reasons for the relapse of the disease.