HEPATOBILIARY SYSTEM FUNCTION IN CHILDREN WITH METABOLIC SYNDROME

Abstract

The purpose was to study the state of the hepatobiliary system in children with metabolic syndrome (MS). Materials and methods. Surveyed 286 children 10-16 years: the main group of 236 children with MS (IDF, 2007), a comparison group of 50 children with normal body weight with diseases of the hepatobiliary system. Performed complex included biochemical examination, ultrasound examination of hepatobiliary system, a CT scan. Statistical processing of results was performed using the package “STATISTIKA 6.0”. The results of the study. Non-alcoholic fatty liver disease (NAFLD) was diagnosed in 70,0% of children of the main group. The mean values of ALT, bilirubin, γ-GTP in children of the main group were significantly higher than in the comparison group, increased ALT was observed in 27,4% of children in the main group. Cholesterosis of gallbladder was detected in 29,9% of children in the main group and 12,0% of children in the comparison group (p < 0,05). Violation of lithogenic properties of bile was observed in 36,7% of children in the main group. The comparison group of children with cholelithiasis was 36,0%. In children of the main group were detected more frequently biliary sludge (BS) (93,1%), in comparison group - stones (77,7%). Waist circumference in children with BS constituited 108,8 ± 12,25 cm, in children with stones - 94,5 ± 6,35 cm, in children without BS and stones - 100,75 ± 11,88 cm. In children with steatosis and different stages of cholelithiasis and cholesterosis of gallbladder were recorded significantly frequently than without it. Conclusions. NAFLD was diagnosed in 70,0% of children with MS, structural changes of the liver parenchyma characterized by the development of diffuse-source process with simultaneous presence of various-sized parcels changed according to the type of steatosis and steatohepatitis. 27% of children wish MS have increased ALT and high risk of developing steatohepatitis. In children with MS are formed by expressed human functional state of the biliary tract - 37% of patients was recorded cholelithiasis and 30% - cholesterosis.