НОВЫЕ ГЕПАТОЛОГИЧЕСКИЕ И НЕВРОЛОГИЧЕСКИЕ КЛИНИЧЕСКИЕ ЭФФЕКТЫ ДЛИННОЦЕПОЧЕЧНЫХ РАСТИТЕЛЬНЫХ ПОЛИПРЕНОЛОВ, ДЕЙСТВУЮЩИИХ НА ПУТЬ ИЗОПРЕНОИДНЫХ МЛЕКОПИТАЮЩИХ

Путь синтеза изопреноидов у млекопитающих (также известный, как мевалонатный путь) является фундаментальным для метаболизма и здоровья организма, а такие соединения, как холестерин (стерольный изопреноид), убихинон (кофермент Q) и долихол (нестерольный изопреноид) имеют огромное значение для биологии и физиологии млекопитающих. Воздействие на путь обмена изопреноидов приводит к новым терапевтическим возможностям, применимым для широкого диапазона различных патологических состояний. Растительные полипренолы являются активными молекулами, которые влияют на путь обмена изопреноидов. При использовании наших полипренолов фармацевтического качества, каковым является Ропрен®, никогда не было зарегистрировано побочных эффектов. Статины и бисфосфонаты также влияют на этот путь обмена, но при этом проявляют множественные побочные эффекты. Наша уникальная возможность производить Ропрен®, содержащий не менее 95% чистых полипренолов, позволила использовать этот препарат в клинической практике в России около 10 лет, а также открыла возможность исследователям проводить клинические испытания для выявления других его терапевтических свойств. Не смотря на то, что полипренолы могут широко применяться для лечения заболеваний, связанных с вирусными, бактериальными и грибковыми инфекциями, воспалениями и другими иммунными состояниями, данная статья представляет новые доклинические и клинические эффекты полипренолов при заболеваниях печени и центральной нервной системы. Недавние доклинические испытания показали, что лечение полипренолами, полученными из хвои, имеет целый ряд неврологических и когнитивных эффектов, включая улучшение когнитивной функции у крыс с заболеванием Альцгеймера и восстановление здорового уровня миелинизации у мышей на модели рассеянного склероза. Более ранние клинические исследования продемонстрировали, что лечение Ропреном® улучшает уровни антиоксидантов у людей с сахарным диабетом, а также улучшает функцию печени у пациентов, проходящих химиотерапию. Ропрен® также оказывает положительное влияние на электроэнцефалограмму у людей с болезнью Альцгеймера и алкогольным циррозом печени и значительно снижает симптомы депрессии у пациентов. Результаты дают основание для проведения более обширных клинических исследований и указывают на то, что Ропрен® является ценным клиническим «инструментом» в лечении целого ряда неврологических и гепатологических заболеваний.

Ропрен, полипренолы, изопреноид, гепатопротектор, неврологические заболевания, мевалонатный путь

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