Prevalence of Helicobacter pylori infection and data on primary resistance to clarithromycin in men aged 18-26 years

The aim of the study to evaluate the incidence of H. pylori infection in men aged 18-26 years (conscripts and conscripts) with symptoms of dyspepsia in 2010-2013 and in 2020-2023, to determine the primary resistance of H. pylori to clarithromycin in 2024. Materials and methods. The results of the study of the frequency of H. pylori in men aged 18-26 years, performed in 2010-2013 and in 2020-2023, the results of the study of primary H. pylori resistance to clarthromycin in 2024. Results. The incidence of H. pylori infection in men aged 18-26 years with symptoms of dyspepsia in 2010-2013 was 61.2% among conscripts (95% CI 52.1-69.6), 65.3% among conscripts (95% CI 59.1-71.1). In 2020-2023, compared with 2010-2013, there was a statistically significant decrease in the incidence of H. pylori in men aged 18-26 years (conscripts) with dyspepsia from 65.3% (95% CI 59.1-71.1) to 49.3% (95% CI 45.3-53.2; χ2 = 17.69; p < 0.001). In 2020-2023, H. pylori in the presence of dyspepsia, in contrast to the period 2010-2013. It was more often detected in conscripts from rural settlements (57.6%; 95% CI 49.5-65.4) compared with conscripts from cities (46.7%; 95% CI 42.2-51.2; χ² = 5.31; p < 0.02). Primary H. pylori resistance to clarithromycin in men aged 18-26 (conscripts) in 2024 was determined by molecular genetic analysis in 13.6% (95% CI 8.3-21.5). Conclusion. Over a ten-year period, the prevalence of H. pylori infection in men aged 18-26 years (conscripts) with dyspepsia decreased.

Helicobacter pylori, gastric mucosa, frequency, resistance, men

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