Preview

Experimental and Clinical Gastroenterology

Advanced search

Successful application of radiofrequency ablation technique in malignant neoplasms of the pancreas

https://doi.org/10.31146/1682-8658-ecg-237-5-132-136

Abstract

Pancreatic cancer is a rather aggressive tumor that grows rapidly and metastasizes relatively early. The diagnosis of PPC is established on the basis of anamnestic, laboratory data and results of instrumental examination, however, nonspecificity of symptoms does not allow to detect the disease at early stages, in a large part of patients pancreatic malignancies are diagnosed already at stage III-IV. Among all neoplasms of the pancreas, neuroendocrine tumors are also distinguished. Radiofrequency ablation is an invasive intervention in which a local action of high temperature is performed locally on the tumor, resulting in the death of neoplastic cells. The method is based on the effect of high-frequency radio waves on pathologic tissues. In the NMI Center of Oncology named after N.N. Blokhin. N.N. Blokhin NMI Oncology Center performed 6 radiofrequency ablations of neuroendocrine tumors of the pancreas under the control of endoscopic ultrasonography. No complications were noted in the postoperative period. All patients were discharged with recommendations under the supervision of an oncologist at the place of residence. It was also noted that the quality of life and further course of the disease improved in patients with the introduction of this method of treatment

About the Authors

O. A. Malikhova
Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of the Russian Federation; Hadassah Medical Moscow
Russian Federation


A. A. Salimova
N.N. Blokhin National Medical Research Center of Oncology
Russian Federation


A. O. Bogdanova
N.N. Blokhin National Medical Research Center of Oncology
Russian Federation


V. A. Komarova
N.N. Blokhin National Medical Research Center of Oncology
Russian Federation


V. V. Lozovaya
N.N. Blokhin National Medical Research Center of Oncology
Russian Federation


A. O. Tumanyan
N.N. Blokhin National Medical Research Center of Oncology
Russian Federation


References

1. Moskvicheva L.I., Petrov L.O., Sidorov D.V. The possibilities of modern methods of ablation in non-resectable locally advanced pancreatic cancer. Research and Practical Medicine Journal. 2018;5(2):86-99. (In Russ.) doi: 10.17709/2409-2231-2018-5-2-10.@@ Москвичева Л.И., Петров Л.О., Сидоров Д.В. Возможности современных методов абляции при нерезектабельном местно-распространенном раке поджелудочной железы. Research’n practical medicine journal. 2018;5(2):86-99. doi: 10.17709/2409-2231-2018-5-2-10.

2. Karpov O.E., Vetshev P.S., Bruslik S.V., Sviridova T.I., Levchuk A.L., Sarzhevskiy V.O., Sudilovskaya V.V. Ultrasound Ablation (HIFU) in the Treatment of Pancreatic Unresectable Tumors. Annaly khirurgicheskoy gepatologii = Annals of HPB Surgery. 2015;20(3):17-23. (In Russ.) doi: 10.16931/1995-5464.2015317-23.@@ Карпов О.Э., Ветшев П.С., Бруслик С.В., Свиридова Т.И., Левчук А.Л., Саржевский В.О., Судиловская В.В. Ультразвуковая абляция (hifu) в лечении нерезектабельных опухолей поджелудочной железы. Анналы хирургической гепатологии. 2015;20(3):17-23. doi: 10.16931/1995-5464.2015317-23.

3. Yashin S.S., Melikdzhanyan M.V., Semenaya E.V., Kozlov G.N., Kraynikova E.A. Pancreatic cancer: review and clinical case. Astrakhan medical journal. 2022;17(3):84-91. (In Russ.) doi: 10.48612/agmu/ 2022.17.3.84.91.@@ Яшин C.C., Меликджанян М.В., Семеная Е.В., Козлов Г.Н., Крайникова Е.А. Рак поджелудочной железы: обзор литературы и описание клинического случая. Астраханский медицинский журнал. 2022;17(3):84-91. doi: 10.48612/agmu/2022.17.3.84.91.

4. Morgoshiia T. Sh. Neuroendocrine tumors of the pancreas: from theory to practical recommendations. Pediatrician (St. Petersburg). 2018;9(1):90-99. doi: 10.17816/PED9190-99.@@ Моргошия T.Ш. Нейроэндокринные опухоли поджелудочной железы: от теории к практическим рекомендациям. педиатр. 2018. Т. 9. № 1. С. 90-99. doi: 10.17816/ped9190-99.

5. Rustagi T., Chhoda A. Endoscopic radiofrequency ablation of the pancreas. Dig dis sci. 2017 apr;62(4):843-850. doi: 10.1007/s10620-017-4452-y.

6. Patyutko Yu.I., Podluzhny D.V., Kotelnikov A.G., Sagaydak I.V. Cryosurgical method in the treatment of patients with malignant tumors of the pancreas.Russian Academy of Sciences, surgical department of liver and pancreas tumors. 2005.@@ Патютко Ю.И., Подлужный Д.В., Котельников А.Г., Сагайдак И.В. Криохирургический метод в лечении больных злокачественными опухолями поджелудочной железы. РАМН, хирургическое отделение опухолей печени и поджелудочной железы. 2005 г.

7. Ahmed M., Solbiati L., Brace C.L., Breen D.J., Callstrom M.R., Charboneau J.W. et al. Image guided tumor ablation: standardization of terminology and reporting criteria - a 10-year update. J vasc interv radiol. 2014 nov;25(11):1691-705.e4. doi: 10.1016/j.jvir.2014.08.027.

8. Zhou Y. High-intensity focused ultrasound treatment for advanced pancreatic cancer. Gastroenterol res pract. 2014;2014:205325. doi: 10.1155/2014/205325.

9. Lin M., Liang S., Wang X., Liang Y., Zhang M., Chen J. et al. Percutaneous irreversible electroporation combined with allogeneic natural killer cell immunotherapy for patients with unresectable (stage iii/iv) pancreatic cancer: a promising treatment. J cancer res clin oncol. 2017 dec;143(12):2607-2618. doi: 10.1007/s00432-017-2513-4.

10. Dagoglu N., Callery M., Moser J., Tseng J., Kent T., Bullock A. et al. Stereotactic body radiotherapy (sbrt) reirradiation for recurrent pancreas cancer. J cancer. 2016 jan 10;7(3):283-8. doi: 10.7150/jca.13295.

11. Paiella S., Salvia R., Girelli R., Frigerio I., Giardino A., D’onofrio M. et al. Role of local ablative techniques (radiofrequency ablation and irreversible electroporation) in the treatment of pancreatic cancer. Updates surg. 2016 sep;68(3):307-311. doi: 10.1007/s13304-016-0385-9.

12. Rustagi T., chhoda A. Endoscopic radiofrequency ablation of the pancreas. Dig dis sci. 2017 apr;62(4):843-850. doi: 10.1007/s10620-017-4452-y.

13. Wu F. High intensity focused ultrasound: a noninvasive therapy for locally advanced pancreatic cancer. World j gastroenterol. 2014 nov 28;20(44):16480-8. doi: 10.3748/wjg.v20.i44.16480.

14. Chang K.J. State of the art lecture: endoscopic ultrasound (eus) and fna in pancreatico-biliary tumors. Endoscopy. 2006; 38 (suppl. 1): 556-60.

15. Clinical guidelines - pancreatic cancer - 2021-2022-2023 (04.06.2021) - approved by the Ministry of Health of the Russian Federation. (in Russ.) Available at: http://disuria.ru/_ld/10/1032_kr21c25mz.pdf (Accessed: 01.01.2025). @@ Клинические рекомендации - рак поджелудочной железы - 2021-2022-2023 (04.06.2021) - утверждены минздравом рф http://disuria.ru/_ld/10/1032_kr21c25mz.pdf

16. Nikulin M.P., Selcuk V. Yu., Chistyakov S.S., Ibragimov T.F., Titova G.V. Pancreatic cancer. RMJ. 2006; 24:1726. (in Russ.)@@ Никулин М.П., Сельчук В.Ю., Чистяков С.С., Ибрагимов Т.Ф., Титова Г.В. Рак поджелудочной железы. РМЖ. 2006;24:1726.


Review

For citations:


Malikhova O.A., Salimova A.A., Bogdanova A.O., Komarova V.A., Lozovaya V.V., Tumanyan A.O. Successful application of radiofrequency ablation technique in malignant neoplasms of the pancreas. Experimental and Clinical Gastroenterology. 2025;(5):132-136. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-237-5-132-136

Views: 10


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1682-8658 (Print)