Pancreatic cancer is a rather aggressive tumor that grows rapidly and metastasizes relatively early. The diagnosis of PPC is established on the basis of anamnestic, laboratory data and results of instrumental examination, however, nonspecificity of symptoms does not allow to detect the disease at early stages, in a large part of patients pancreatic malignancies are diagnosed already at stage III-IV. Among all neoplasms of the pancreas, neuroendocrine tumors are also distinguished. Radiofrequency ablation is an invasive intervention in which a local action of high temperature is performed locally on the tumor, resulting in the death of neoplastic cells. The method is based on the effect of high-frequency radio waves on pathologic tissues. In the NMI Center of Oncology named after N.N. Blokhin. N.N. Blokhin NMI Oncology Center performed 6 radiofrequency ablations of neuroendocrine tumors of the pancreas under the control of endoscopic ultrasonography. No complications were noted in the postoperative period. All patients were discharged with recommendations under the supervision of an oncologist at the place of residence. It was also noted that the quality of life and further course of the disease improved in patients with the introduction of this method of treatment