A PROTECTIVE ROLE FOR MAGNESIUM 2-AMINOETHANSULFONATE IN PARACETAMOL AND ETHANOL-INDUCED LIVER INJURY IN PREGNANT RATS
Abstract
The goal: to investigate a preventive activity for novel medication magnesium 2-aminoethansulfonate in experimental hepatitis in pregnant rats. Material and Methods. The study has been conducted in firs week pregnant rats with paracetamol and ethanol-induced liver injury. Results. There has been found out that new domestic compound magnesium 2-aminoethansulfonate (laboratory name LBK-527) introduced daily at a dose of 28 mg/kg per os during 6 days, limits cytolysis and cholestasis caused by either paracetamol or ethanol intake in experiments in pregnant rats. Study shows that liver of the animals, that have been given LBK-527 simultaneously with either 500 mg/kg paracetamol or 10 ml/kg 40% ethanol, remains being structurally close to normal. The substance prevents acute toxic liver dystrophy and the organ’s structure disintegration made by mentioned toxic agents. Having administered at a therapeutic dose LBK-527 isn’t associated with faetotoxicity and embriototoxity in experiments in rats.
About the Authors
E. V. Blinova
Ogarev Mordovia State University, Novel Medications Research Center
Russian Federation
Russian Federation
M. A. Halzova
Ogarev Mordovia State University, Novel Medications Research Center
Russian Federation
Russian Federation
D. S. Blinov
Ogarev Mordovia State University, Novel Medications Research Center
Russian Federation
Russian Federation
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Review
For citations:
Blinova E.V., Halzova M.A., Blinov D.S. A PROTECTIVE ROLE FOR MAGNESIUM 2-AMINOETHANSULFONATE IN PARACETAMOL AND ETHANOL-INDUCED LIVER INJURY IN PREGNANT RATS. Experimental and Clinical Gastroenterology. 2016;(10):50-53. (In Russ.)
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