Study of clinical features of genetic polymorphism of the enzyme diamine oxidase in children and adolescents
https://doi.org/10.31146/1682-8658-ecg-233-1-59-64
Abstract
Aim. To develop a non-invasive method for diagnosing reflux esophagitis in patients with comorbid pathology: HP associated chronic gastritis and atopic dermatitis. Materials and methods. Two groups of children were examined: 60 had AtD and HP+CG and 30 had HP+CG without At D. Risk factors were selected on the basis of clinical, anamnestic, laboratory, and instrumental data, a decision tree was created as well. Conclusion. The conducted research allowed us to develop a plausible non-invasive method for diagnosing reflux esophagitis in children with AtD and HP+CG. Every risk factor (female gender, complaints of bitterness in the mouth, heartburn, abdominal pain, increased fat mass according to impedanceometry and increased level of zonulin in feces) is estimated as 1 point; the sum of points 5 and more indicates the presence of reflux esophagitis with a probability of 94.1% (invention application № 2024139936 from 26.12.2024).
About the Authors
E. V. Shrayner
Novosibirsk State University; Institute of Chemical Biology and Fundamental Medicine of the Siberian Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
A. I. Khavkin
Research and Clinical Institute of Childhood, Ministry of Health of the Moscow Region; Belgorod State Research University. Ministry of Science and Higher Education of the Russian Federation
Russian Federation
Russian Federation
V. I. Bystrova
Novosibirsk State University; Institute of Chemical Biology and Fundamental Medicine of the Siberian Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
G. I. Lifshits
Novosibirsk State University; Institute of Chemical Biology and Fundamental Medicine of the Siberian Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
E. N. Voronina
Institute of Chemical Biology and Fundamental Medicine of the Siberian Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
M. Yu. Denisov
Novosibirsk State University
Russian Federation
Russian Federation
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Review
For citations:
Shrayner E.V., Khavkin A.I., Bystrova V.I., Lifshits G.I., Voronina E.N., Denisov M.Yu. Study of clinical features of genetic polymorphism of the enzyme diamine oxidase in children and adolescents. Experimental and Clinical Gastroenterology. 2025;(1):59-64. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-233-1-59-64
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