Зонулин и его роль в возникновении младенческих колик: механизмы взаимосвязи

Цель. На основании изучения научных источников выявить механизмы связи между воздействием белка зонулина на кишечную стенку и возникновением младенческих колик. Материалы и методы. Произведен поиск научных статей в базах данных PubMed, Scopus, Web of Science, F1000Research. Отобрано 96 источников, опубликованных в период с 1991 по 2023 год. Результаты. Представлены сведения об истории открытия белка зонулина, а также современный взгляд на строение плотных межклеточных соединений эпителия кишечника, описаны процессы, посредством которых осуществляется эффект зонулина в отношении изменения проницаемости кишечного барьера. Приведены данные нескольких исследований, в которых было обнаружено повышение уровня зонулина в группах детей с коликами и с дисфункцией ЖКТ. Произведен обзор работ, в которых отмечена связь зонулина с внекишечной патологией - психическими расстройствами, эндокринными, аутоиммунными, сердечно-легочными, аллергическими, инфекционными заболеваниями. Зонулин является перспективной фармакологической мишенью - на сегодняшний день существует специфическая молекула-ингибитор зонулина, показывающая эффективность в лечении целиакии и мультисистемного воспалительного синдрома у детей. Заключение. Анализ научных публикаций свидетельствует о несомненной актуальности изучения зонулина, как фактора, влияющего на проницаемость кишечной стенки и ряд других процессов. Его роль в формировании кишечных колик требует более детального изучения, поскольку открытия в этой области могут быть активно интегрированы в клиническую практику.

зонулин, проницаемость кишечника, кишечный барьер

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