Recurrent esophageal candidiasis resistant to fluconazole, complicated by stricture, in a patient with idiopathic immune dysfunction
https://doi.org/10.31146/1682-8658-ecg-212-4-152-157
Abstract
A clinical case of a 62-year-old patient in whom recurrent esophageal candidiasis led to a complication - stricture of the cervical esophagus is presented. The immune dysfunction clarified with the help of an immunological study was characterized by a combined defect in the effectiveness of inflammation, phagocytosis and cytotoxicity, but its cause was not established. In this patient, previous repeated courses of treatment with fluconazole led to the selection of a strain of Candida albicans resistant to fluconazole, therefore, candidiasis was treated with an alternative drug - voriconazole.
About the Authors
M. A. Shevyakov
North-Western state medical University named after I. I. Mechnikov
Russian Federation
Russian Federation
S. M. Kulakova
North-Western state medical University named after I. I. Mechnikov
Russian Federation
Russian Federation
M. M. Snytko
Bryansk Regional Hospital No. 1
Russian Federation
Russian Federation
A. S. Kulakov
North-Western state medical University named after I. I. Mechnikov
Russian Federation
Russian Federation
E. V. Frolova
North-Western state medical University named after I. I. Mechnikov
Russian Federation
Russian Federation
E. A. Desyatik
North-Western state medical University named after I. I. Mechnikov
Russian Federation
Russian Federation
V. S. Mitrofanov
North-Western state medical University named after I. I. Mechnikov
Russian Federation
Russian Federation
References
1. Shevyakov M.A., Antonov V. B., Zagorskaya E. A. [Esophageal strictures of candidal etiology]. Vestnik khirurgii im. I. I. Grekova, 1991;(3):39-40. (in Russ.)@@ Шевяков М. А., Антонов В. Б., Загорская Е. А. Стриктуры пищевода кандидозной этиологии // Вестник хирургии им. И. И. Грекова, 1991, № 3, с. 39-40.
2. Elinov N.P., Vasilyeva N. V., Raush E. R., Dorshakova E. V. [Rational scientific and practical terminology of pathogenic and opportunistic fungi and the diseases they cause]. St. Petersburg: NWSMU Publ., 2014. (in Russ.)@@ Елинов Н. П., Васильева Н. В., Рауш Е. Р., Доршакова Е. В. Рациональная научно-практическая терминология патогенных и условно-патогенных грибов и вызываемых ими заболеваний. Учебное пособие. - СПб: СЗГМУ им. И. И. Мечникова, 2014.
3. Klimko N.N. [Mycoses: diagnosis and treatment]. 3rd. Rev. Moscow. Pharmtek Publ., 2017. 272 p. (in Russ.)@@ Климко Н. Н. Микозы: диагностика и лечение. Руководство для врачей. 3-е изд. Перераб. И доп. - М.: Фармтек, 2017. - 272 с.
4. Pappas P.G., Kauffman C. A., Andes D. R., et al. Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America. Clin Infect Dis. 2016 Feb 15;62(4): e1-50. doi: 10.1093/cid/civ933.
5. Mohamed A.A., Lu X. L., Mounmin F. A. Diagnosis and Treatment of Esophageal Candidiasis: Current Updates. Can J Gastroenterol Hepatol. 2019 Oct 20;2019:3585136. doi: 10.1155/2019/3585136.
Review
For citations:
Shevyakov M.A., Kulakova S.M., Snytko M.M., Kulakov A.S., Frolova E.V., Desyatik E.A., Mitrofanov V.S. Recurrent esophageal candidiasis resistant to fluconazole, complicated by stricture, in a patient with idiopathic immune dysfunction. Experimental and Clinical Gastroenterology. 2023;(4):152-157. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-212-4-152-157
Views:
471
Email this article 