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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nogr</journal-id><journal-title-group><journal-title xml:lang="ru">Экспериментальная и клиническая гастроэнтерология</journal-title><trans-title-group xml:lang="en"><trans-title>Experimental and Clinical Gastroenterology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-8658</issn><publisher><publisher-name>«Global Media Technologies»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31146/1682-8658-ecg-212-4-152-157</article-id><article-id custom-type="elpub" pub-id-type="custom">nogr-2375</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL CASES</subject></subj-group></article-categories><title-group><article-title>Рецидивирующий кандидоз пищевода, резистентный к флуконазолу, осложненный стриктурой, у пациентки с идиопатической иммунной дисфункцией</article-title><trans-title-group xml:lang="en"><trans-title>Recurrent esophageal candidiasis resistant to fluconazole, complicated by stricture, in a patient with idiopathic immune dysfunction</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шевяков</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Shevyakov</surname><given-names>M. A.</given-names></name></name-alternatives><email xlink:type="simple">shevyakov@inbox.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кулакова</surname><given-names>С. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Kulakova</surname><given-names>S. M.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Снытко</surname><given-names>М. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Snytko</surname><given-names>M. M.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кулаков</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Kulakov</surname><given-names>A. S.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Фролова</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Frolova</surname><given-names>E. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Десятик</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Desyatik</surname><given-names>E. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Митрофанов</surname><given-names>В. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Mitrofanov</surname><given-names>V. S.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное образовательное учреждение высшего образования Северо - Западный государственный медицинский университет им. И. И. Мечникова Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>North-Western state medical University named after I. I. Mechnikov</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Государственное автономное учреждение здравоохранения «Брянская областная больница № 1»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Bryansk Regional Hospital No. 1</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>26</day><month>07</month><year>2023</year></pub-date><volume>0</volume><issue>4</issue><fpage>152</fpage><lpage>157</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Шевяков М.А., Кулакова С.М., Снытко М.М., Кулаков А.С., Фролова Е.В., Десятик Е.А., Митрофанов В.С., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Шевяков М.А., Кулакова С.М., Снытко М.М., Кулаков А.С., Фролова Е.В., Десятик Е.А., Митрофанов В.С.</copyright-holder><copyright-holder xml:lang="en">Shevyakov M.A., Kulakova S.M., Snytko M.M., Kulakov A.S., Frolova E.V., Desyatik E.A., Mitrofanov V.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.nogr.org/jour/article/view/2375">https://www.nogr.org/jour/article/view/2375</self-uri><abstract><p>Представлен клинический случай пациентки 62 лет, у которой рецидивирующий кандидоз пищевода привел к осложнению - стриктуре шейного отдела пищевода. Уточненная с помощью иммунологического исследования иммунная дисфункция характеризовалась сочетанным дефектом эффективности воспаления, фагоцитоза и цитотоксичности, однако причина ее установлена не была. У данной пациентки ранее проводимые повторные курсы лечения флуконазолом привели к селекции штамма Cаndida albicans, резистентного к флуконазолу, поэтому лечение кандидоза проводили альтернативным препаратом - вориконазолом.</p></abstract><trans-abstract xml:lang="en"><p>A clinical case of a 62-year-old patient in whom recurrent esophageal candidiasis led to a complication - stricture of the cervical esophagus is presented. The immune dysfunction clarified with the help of an immunological study was characterized by a combined defect in the effectiveness of inflammation, phagocytosis and cytotoxicity, but its cause was not established. In this patient, previous repeated courses of treatment with fluconazole led to the selection of a strain of Candida albicans resistant to fluconazole, therefore, candidiasis was treated with an alternative drug - voriconazole.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>кандидоз пищевода</kwd><kwd>кандидоз ротоглотки</kwd><kwd>стриктура пищевода</kwd><kwd>стеноз пищевода</kwd><kwd>иммунная дисфункция</kwd><kwd>флуконазол</kwd><kwd>вориконазол</kwd><kwd>Candida</kwd></kwd-group><kwd-group xml:lang="en"><kwd>esophageal candidiasis</kwd><kwd>oropharyngeal candidiasis</kwd><kwd>esophageal stricture</kwd><kwd>esophageal stenosis</kwd><kwd>immune dysfunction</kwd><kwd>fluconazole</kwd><kwd>voriconazole</kwd><kwd>Candida</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Shevyakov M.A., Antonov V. B., Zagorskaya E. A. [Esophageal strictures of candidal etiology]. 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