LIPID PROFILE AND LIVER DISEASES AMONG PATIENTS WITH MORBID OBESITY
Abstract
Objectives. The aim of our study was to investigate associations between the lipid profile, liver condition and the level of BMI. Methods. Our sample consisted of 58 patients: 30 - with morbid obesity and BMI - 40-49 (1 group), 28 - with superobesity, BMI - 50-69 (2 group). Lipids and hepatic functional tests were measured just prior to surgery. Ultrasound examination was used to estimate liver condition. Liver biopsy specimens were obtained at the time of surgery, classified according to the nonalcoholic fatty liver disease and steatohepatitis activity score. Results. Lower level of cholesterol has been found in the first group with morbid obesity. Higher level of triglycerides and very low-density lipoprotein has been found in the second group with superobesity (р=0,000 ANOVA). High-density lipoprotein was normal but significantly associated with BMI. The level of low-density lipoprotein was higher in the second group, but the difference between ptoups was not significant. BMI was associated with higher scores of ultrasonographic parameters and severity of steatosis, the increased prevalence of steatohepatitis and it activity. We also realized the positive correlation between ultrasonographic parameters and histological features. Conclusion. BMI has significantly positive correlations with the level of triglycerides and very low-density lipoprotein, ultrasonographic parameters, histological features of steatosis and steatohepatitis. The level of total cholesterol did not reflect all changes of lipid profile.
About the Authors
L. P. Kotelnikova
Perm State Medical University named after Ac. E. A. Vagner
Russian Federation
Russian Federation
R. A. Stepanov
Perm State Medical University named after Ac. E. A. Vagner
Russian Federation
Russian Federation
G. G. Freind
Perm State Medical University named after Ac. E. A. Vagner
Russian Federation
Russian Federation
References
1. Алексеева О. П. Метаболический синдром: современное понятие, факторы риска и некоторые ассоциированные заболевания/ О. П. Алексеева [и др.]. - Н. Новгород: изд-во НижГМА, 2009.-112 с.
2. Gut DP, Zhang W., Bansback N. et al. The incidence of comorbidities related to obesity and overweight: a systematic review and meta-analysis. BMC Public Health. 2009; 9.
3. Дедов И. И. Ожирение/ И. И. Дедов [и др.]. - М.: Медицинское информационное агентство, 2004. - 449 с.
4. Мамедов М. Н. Метаболический синдром в реальных клинико-амбулаторных условиях: принципы диагностики и лечения/ М. Н. Мамедов, Р. Г. Оганов// Профилактика заболеваний и укрепление здоровья. - 2005. - N 6. - С. 41-45.
5. Буеверов А. О. Неалкогольная жировая болезнь печени и неалкогольный стеатогепатит/ А. О. Буеверов// Врач. - 2006. - № 7. - С. 33-37.
6. Вовк Е. И. Жировая болезнь печени в практике терапевта/ Е. И. Вовк// Рус. мед. жур. - 2009. - Т. 11, № 2. - С. 33-47.
7. Егорова Е. Г. Печень и метаболический синдром/ Е. Г. Егорова, Л. Ю. Ильченко// Гепатология. - 2005. - № 4. - С. 28-35.
8. Ren-Jow Liang. Diagnostic Value of Ultrasonographic Examination for Nonalcoholic Steatohepatitis in Morbidly Obese Patients Undergoing Laparoscopic Bariatric Surgery/ Ren-Jow Liang, Hsih-Hsi Wang et al. // Obesity Surgery. - 2007. - Vol. 17, № 1. - P. 45-56.
9. Ройтберг Г. Е. Роль метаболического синдрома и его компонентов в патогенезе и прогрессировании неалкогольного стеатогепатита/ Г. Е. Ройтерберг [и др.]// Гепатология. - 2005. - № 5. - С. 30-36.
10. Седлецкий И. Ю. Хирургическое лечение ожирения и дислипидемий. / И. Ю. Седлецкий, Л. В. Лебедев, К. К. Мирчук. - С-П.: Гиппократ, 2005. - 248 с.
11. Кривцова Е. В. Метаболический статус и эндокринопатии у бариатрических больных с различной степенью ожирения/ Е. В. Кривцова [и др.]// Анналы хирургии. Приложение. Материалы Пятого Российского симпозиума с международным участием «Хирургическое лечение ожирения и метаболических нарушений». - Самара, 2009. - С. 69-71.
12. Хазанов А. И. Возможности прогрессирования алкогольного и неалкогольного стеатогепатита в цирроз печени/ А. И. Хазанов// Рос. журн. гастроэнтерол. гепатол. колопроктол. - 2005. - Т. 15, № 2. - С. 26-32.
13. Lebovics E., Rubin J. Non-alcoholic fatty liver disease (NAFLD): why you should care, when you should worry, what you should do. Diabetes Metab Res Rev. 2011; 27: 419-424.
14. Praveenraj P., Gomes R. M., Kumar S. et al. Prevalence and predictors of non-alcoholic fatty liver disease in morbidly obese south Indians patients undergoing bariatric surgery. Obesity Surgery. 2015, v. 25, N11, P. 2078-2092.
15. Chong-Chi Chiu. Correlations of Laparoscopy with Histology and Laboratory Studies on Liver Diseases in Bariatric Patients/ Chong-Chi Chiu, Wei-Jei Lee, Weu Wang, Yi-Chih Lee// Obesity Surgery. - 2008. - Vol. 18, № 2. - P. 204-211.
Review
For citations:
Kotelnikova L.P., Stepanov R.A., Freind G.G. LIPID PROFILE AND LIVER DISEASES AMONG PATIENTS WITH MORBID OBESITY. Experimental and Clinical Gastroenterology. 2016;(6):48-51. (In Russ.)
Views:
278
Email this article 