Involvement of endoand exoantigens in the development of the autoimmune reaction
I. E. Trubitsyna,
E. A. Dubtsova,
Z. M. Abdulatipova,
E. . Moskaeva,
T. V. Tarasova,
A. V. Smirnova,
I. N. Ruchkina,
N. N. Vorobyova,
K. A. Lesko,
M. . Malykh,
I. S. Vasilyeva,
V. V. Vasiliev,
L. D. Papysheva,
T. V. Kleshcheva,
V. V. Kleshchev,
L. I. Efremov,
G. . Drozdova,
L. V. Vinokurova https://doi.org/10.31146/1682-8658-ecg-204-8-113-118
Abstract
The immune inflammatory reaction is involved in the formation of structural damage in organs with low immune resistance, but the causal stages of the formation of this reaction are poorly understood. Clinicians are faced with the fact that in patients with acute and chronic pancreatitis of alcoholic etiology, a reactive inflammatory reaction is observed in the mucous membrane (MM) of the stomach and / or duodenum. This effect was the reason that experimental studies were carried out on 45 white Wistar rats weighing 180-220 g. and duodenum (DOD). For this, a classical immunization scheme was used. Rats were taken out of the experiment on days 5, 10, and 17; after autopsy, morphological studies of the pancreas, gastric mucosa, and SOD were performed. Undoubtedly, the emerging immune response of the macroorganism to damage contributes to the development of an autoimmune reaction, in response to destruction and an inflammatory reaction, as a result, structural and functional damage to its own tissues occurs. The involvement of several organs in the inflammatory reaction depends on the local immune tolerance of the organ to endoantigens. A decrease in tolerance leads to a combined pathology, the impetus for which is damage to the “primary” organ, which is not always possible to identify. At the same time, antibodies to endoantigens are formed from damaged cellular structures.
About the Authors
I. E. Trubitsyna
Moscow Clinical Research Center named after A. S. Loginova Department of Health of Moscow
Russian Federation
Russian Federation
E. A. Dubtsova
Moscow Clinical Research Center named after A. S. Loginova Department of Health of Moscow
Russian Federation
Russian Federation
Z. M. Abdulatipova
Moscow Clinical Research Center named after A. S. Loginova Department of Health of Moscow
Russian Federation
Russian Federation
E. . Moskaeva
Peoples’ Friendship University of Russia
Russian Federation
Russian Federation
T. V. Tarasova
Mordovian State University Ogareva
Russian Federation
Russian Federation
A. V. Smirnova
Moscow Clinical Research Center named after A. S. Loginova Department of Health of Moscow; Federal State Budgetary Institution “National Medical Research Cancer Center named after N. N. Blokhin” of the Ministry of Health of Russia
Russian Federation
Russian Federation
I. N. Ruchkina
Moscow Clinical Research Center named after A. S. Loginova Department of Health of Moscow
Russian Federation
Russian Federation
N. N. Vorobyova
Moscow Clinical Research Center named after A. S. Loginova Department of Health of Moscow
Russian Federation
Russian Federation
K. A. Lesko
Moscow Clinical Research Center named after A. S. Loginova Department of Health of Moscow
Russian Federation
Russian Federation
M. . Malykh
Moscow Clinical Research Center named after A. S. Loginova Department of Health of Moscow
Russian Federation
Russian Federation
I. S. Vasilyeva
State Budgetary Health Institution of the Moscow Region “Moscow Regional Research Clinical Institute named after V.I. M. F. Vladimirsky”
Russian Federation
Russian Federation
V. V. Vasiliev
State Budgetary Health Institution of the Moscow Region “Moscow Regional Research Clinical Institute named after V.I. M. F. Vladimirsky”
Russian Federation
Russian Federation
L. D. Papysheva
Moscow Clinical Research Center named after A. S. Loginova Department of Health of Moscow
Russian Federation
Russian Federation
T. V. Kleshcheva
Financial University under the Government of the Russian Federation
Russian Federation
Russian Federation
V. V. Kleshchev
Financial University under the Government of the Russian Federation
Russian Federation
Russian Federation
L. I. Efremov
Moscow Clinical Research Center named after A. S. Loginova Department of Health of Moscow
Russian Federation
Russian Federation
G. . Drozdova
Peoples’ Friendship University of Russia
Russian Federation
Russian Federation
L. V. Vinokurova
Moscow Clinical Research Center named after A. S. Loginova Department of Health of Moscow
Russian Federation
Russian Federation
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For citations:
Trubitsyna I.E., Dubtsova E.A., Abdulatipova Z.M., Moskaeva E., Tarasova T.V., Smirnova A.V., Ruchkina I.N., Vorobyova N.N., Lesko K.A., Malykh M., Vasilyeva I.S., Vasiliev V.V., Papysheva L.D., Kleshcheva T.V., Kleshchev V.V., Efremov L.I., Drozdova G., Vinokurova L.V. Involvement of endoand exoantigens in the development of the autoimmune reaction. Experimental and Clinical Gastroenterology. 2022;(8):113-118. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-204-8-113-118
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