Современное представление о витамине D и генетической регуляции воспаления на примере различных клинических моделей

В основе концепции настоящего обзора литературы положена научная гипотеза о том, что воспаление, являющееся основой различных заболеваний, имеет общие особенности, этапы, патофизиологически активные вещества, контролирующие активность воспалительных реакций, и общий генетический контроль. В настоящем обзоре литературы отдельные заболевания на основе ведущих патогенетических механизмов воспаления сгруппированы в несколько моделей: аутоиммунную, микробную, лимфопролиферативную, метаболическую, аллергическую. В связи со значением 25 (ОН) D для здоровья человека, его роли в патогенезе ряда заболеваний, многообразием функций и сложностью метаболизма, обусловленного полиморфизмом генов-регуляторов, с одной стороны представляется весьма актуальным мониторинг обеспеченности этим биологически активным эффектором различных групп населения, а также, своевременное выявление недостаточной обеспеченности и необходимости дополнительного приема витамина D, переходом на таргетную терапию при необходимости, а с другой стороны изучение отдельных особенностей молекулярно-генетических механизмов его влияния на течение и исход заболеваний с различными патофизиологическими механизмами воспаления.

дети, витамин D, дефицит 25(OH)D, воспаление, цитокины, VDR

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