nogrЭкспериментальная и клиническая гастроэнтерологияExperimental and Clinical Gastroenterology1682-8658«Global Media Technologies»10.31146/1682-8658-ecg-203-7-192-203nogr-2029Research ArticleОБЗОРREVIEWСовременное представление о витамине D и генетической регуляции воспаления на примере различных клинических моделейModern understanding of vitamin D and the genetic regulation of inflammation in various clinical modelshttps://orcid.org/0000-0002-3043-8674ЛошковаЕлена ВладимировнаLoshkovaElena V.loshkova@rambler.ruhttps://orcid.org/0000-0001-6395-0407КондратьеваЕлена ИвановнаKondratyevaElena I.noemail@neicon.ruhttps://orcid.org/0000-0001-5214-8072ОдинаеваНуринисо ДжумаевнаOdinaevaNuriniso D.noemail@neicon.ruhttps://orcid.org/0000-0001-7308-7280ХавкинАнатолий ИльичKhavkinAnatoly I.noemail@neicon.ruГБУЗ МО «НИКИ детства Министерства здравоохранения Московской области»РоссияChilrden’s Clinical Multidisciplinary Center of the Moscow regionRussian Federation20220710202207192203Copyright © Лошкова Е.В., Кондратьева Е.И., Одинаева Н.Д., Хавкин А.И., 20222022Лошкова Е.В., Кондратьева Е.И., Одинаева Н.Д., Хавкин А.И.Loshkova E.V., Kondratyeva E.I., Odinaeva N.D., Khavkin A.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nogr.org/jour/article/view/2029

В основе концепции настоящего обзора литературы положена научная гипотеза о том, что воспаление, являющееся основой различных заболеваний, имеет общие особенности, этапы, патофизиологически активные вещества, контролирующие активность воспалительных реакций, и общий генетический контроль. В настоящем обзоре литературы отдельные заболевания на основе ведущих патогенетических механизмов воспаления сгруппированы в несколько моделей: аутоиммунную, микробную, лимфопролиферативную, метаболическую, аллергическую. В связи со значением 25 (ОН) D для здоровья человека, его роли в патогенезе ряда заболеваний, многообразием функций и сложностью метаболизма, обусловленного полиморфизмом генов-регуляторов, с одной стороны представляется весьма актуальным мониторинг обеспеченности этим биологически активным эффектором различных групп населения, а также, своевременное выявление недостаточной обеспеченности и необходимости дополнительного приема витамина D, переходом на таргетную терапию при необходимости, а с другой стороны изучение отдельных особенностей молекулярно-генетических механизмов его влияния на течение и исход заболеваний с различными патофизиологическими механизмами воспаления.

The concept of this literature review is based on the scientific hypothesis that inflammation, which is the basis of various diseases, has common features, stages, pathophysiologically active substances that control the activity of inflammatory reactions, and general genetic control. In this literature review, individual diseases are grouped into several models based on the leading pathogenetic mechanisms of inflammation: autoimmune, microbial, lymphoproliferative, metabolic, and allergic. In connection with the importance of 25(OH) D for human health, its role in the pathogenesis of a number of diseases, the diversity of functions and the complexity of metabolism due to polymorphism of regulatory genes, on the one hand, it seems very important to monitor the supply of this biologically active effector to various population groups, as well as, timely detection of insufficient supply and the need for additional intake of vitamin D, switching to targeted therapy if necessary, and on the other hand, the study of certain features of the molecular genetic mechanisms of its influence on the course and outcome of diseases with various pathophysiological mechanisms of inflammation.

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The authors declare that there are no conflicts of interest present.