Experience of liver transplantation in the regional clinical hospital
https://doi.org/10.31146/1682-8658-ecg-203-7-145-150
Abstract
The purpose of the study is to summarize the first experience of liver transplants. Material and methods. Liver transplantation was performed at the Regional Clinical Hospital. 5 liver transplants from a posthumous donor were performed. Based on the available data, the analysis was carried out according to the following criteria: gender, age, MELD- Na index, cause of liver cirrhosis, method of liver transplantation, duration of surgery, postoperative complications, average bed-day, outcome. Results. In total, 5 liver transplants were performed from a posthumous donor. Among the patients there was 1 man and 4 women. The age of men is 41 years, women are 55.4 ± 9.2 years on average. The MELD- Na index is from 15 to 28, on average 17.8 ± 5.1. When transplanting a cadaveric liver, the method of classical orthotopic liver transplantation was used in 4 cases, in one the piggyback technique was used. The duration of surgical intervention in minutes averaged 394 ± 17.4. Postoperative complications on the Clavien-Dindo scale ranged from I to IIIb. The average bed-day of the patient’s stay in the hospital is 20.2 ± 8.9, including 6.2 ± 1.7 days in the intensive care unit. In all 5 cases, the outcome of liver transplantation is satisfactory. Conclusion. The first results of liver transplantation on the basis of the Regional Clinical Hospital showed that performing such a level of operations is possible in a multidisciplinary medical institution.
About the Authors
Oleg V. Zaitsev
Regional Clinical Hospital; Ryazan State Medical University
Russian Federation
Russian Federation
A. R. Monakhov
Research Institute of Transplantology and Artificial Organs
Russian Federation
Russian Federation
S. I. Zubenko
Research Institute of Transplantology and Artificial Organs
Russian Federation
Russian Federation
Anna V. Koshkina
Regional Clinical Hospital; Ryazan State Medical University
Russian Federation
Russian Federation
References
1. Got`e S.V., Homyakov S. M., Arzumanov S. V. et al. Liver transplantation. National clinical guidelines. 2013: 6-9. (In Russ.) @@Готье С. В., Хомяков С. М., Арзуманов С. В. и соавт. Трансплантация печени. Национальные клинические рекомендации. 2013: 6-9.
2. Yupatov H. I., Pryshchepenko V. A. Algorithm of diagnosis and differential diagnosis of chronic diffuse liver diseases (chronic hepatitis and liver cirrhosis) in difficult clinical situations, based on determination of enzymatic activities of blood serum. Science of the young (Eruditio Juvenium). 2020;8(4):566-73. (In Russ.) doi:10.23888/HMJ202084566-573 @@Юпатов Г. И., Прищепенко В. А. Алгоритм диагностики и дифференциальной диагностики хронических диффузных заболеваний печени (хронического гепатита и цирроза печени) в трудных клинических ситуациях, основанный на определении ферментативных активностей сыворотки крови. Наука молодых (Eruditio Juvenium). 2020;8(4):566-73. doi:10.23888/HMJ202084566-573
3. Konovalova E. Yu., Lavrova A. E., Presnyakova M. V. Endothelial dysfunction and platelet function disorder in hemostasis indevelopmentof hepatic fibrosis in children with autoimmunehepatitis. I. P. Pavlov Russian Medical Biological Herald. 2018; 26 (4): 500-510. (In Russ.) doi: 10.23888/PAVLOVJ2018264500-510 @@Коновалова Е. Ю., Лаврова А. Е., Преснякова М. В. Дисфункция эндотелия и нарушение тромбоцитарного звена гемостаза при развитии фиброза печени у детей с аутоиммунным гепатитом. Российский медико-биологический вестник имени академика ИП Павлова. 2018; 26 (4): 500-510. doi:10.23888/PAVLOVJ2018264500-510
4. Liver diseases according to Schiff. Cirrhosis of the liver and its complications. Liver transplantation. Moscow, GEOTAR- Media Publ., 2012. (In Russ.) @@Болезни печени по Шиффу. Цирроз печени и его осложнения. Трансплантация печени. - Москва: ГЕОТАР- Медиа, 2012.
5. Transplantology: a guide for doctors. Мoscow., Medicinskoe informacionnoe agenstvo Publ., 2006. (In Russ.) @@Трансплантология: руководство для врачей. - Москва: Медицинское информационное агенство, 2006.
6. Bussutil R. W., Klintmalm G. K. Transplantation of the liver 3rd edition. Philadelphia: Elsevier Saunders. 2015: 1485.
7. Ivanov P. A. Historical background of the development of liver transplantation in Russia. Transplantology. 2009; 2: 55. (In Russ.) doi:10.23873/2074-0506-2009-0-2-54-56 @@Иванов П. А. Исторические предпосылки к развитию трансплантации печени в России. Трансплантология. 2009; 2: 55. https://doi.org/10.23873/2074-0506-2009-0-2-54-56
8. Polyakov A. V. 30 years of liver transplantation in Russia. Bulletin of the Council of Young Scientists and Specialists of the Chelyabinsk Region. 2020; 1 (1(28)): 26-29. (In Russ.) @@Поляков А. В. 30 лет трансплантации печени в России. Вестник Совета молодых учёных и специалистов Челябинской области. 2020; 1 (1(28)): 26-29. УДК 616.36-002 ББК 54.135
9. Alcoholic liver disease. Part 1: Alcoholic hepatosis and alcoholic hepatitis: (clinic, diagnosis, principles of therapy): methodological recommendations. Petrozavodsk, IntelTek Publ., 2004. (In Russ.) @@Алкогольная болезнь печени. Ч. 1: Алкогольный гепатоз и алкогольный гепатит: (клиника, диагностика, принципы терапии): методические рекомендации. - Петрозаводск: ИнтелТек, 2004.
10. Eremina E. Yu. Alcoholic liver disease. Archive of Internal Medicine. 2012; 6(8): 50-55. (In Russ.) doi:10.20514/2226-6704-2012-0-6-50-54 @@Еремина Е. Ю. Алкогольная болезнь печени. Архив внутренней медицины. 2012; 6(8): 50-55. doi:10.20514/2226-6704-2012-0-6-50-54
11. Abbitan C., Lieber С. Alcoholic liver disease. Perspect. In Gastroenterol. 1999; Sept.Oct.: 257-263.
12. Deuffic-Burban S., Wong J. B., Valleron A. J., et al.Comparing the public health burden of chronic hepatitis С and HIV infection in France. Journal of hepatology. 2004; 40: 319-326. doi:10.1016/j.jhep.2003.10.018
13. Iredale J. P. Cirrhosis: new research provides a basis for rational and targeted treatments. BMJ. 2003; 327 (7407): 143-147. doi: 10.1136/bmj.327.7407.143
Review
For citations:
Zaitsev O.V., Monakhov A.R., Zubenko S.I., Koshkina A.V. Experience of liver transplantation in the regional clinical hospital. Experimental and Clinical Gastroenterology. 2022;(7):145-150. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-203-7-145-150
Views:
353
Email this article 