Photodynamic therapy in the palliative treatment of a stage IV Klatskin tumor
E. F. Stranadko,
A. I. Lobakov,
V. A. Morokhotov,
M. V. Riabov,
N. V. Karpov,
S. V. Morozov,
V. K. Shubin,
Y. K. Bogomazov https://doi.org/10.31146/1682-8658-ecg-201-5-148-153
Abstract
Klatskin tumor is a perihilar cholangiocarcinoma of the lobar and common hepatic ducts (liver port cancer) which is localized proximally to the confluence of common hepatic and cystic ducts (before segmental hepatic ducts of the second order). Currently, photodynamic therapy (PDT) is recommended for the complex management of patients with inoperable extrahepatic cholangiocarcinoma because the discussed PDT technique significantly increases the life expectancy in comparison to the isolated palliative therapy.
A clinical case presented in the article demonstrates the effectiveness of PDT technique in case of cholangiocarcinoma of bifurcation of the common hepatic duct T4N1M1, Bismuth-IV in combination with external drainage of bile ducts in order to resolve the mechanical jaundice.
Conclusion. A significant effect of PDT application in a patient with inoperable Klatskin tumor is demonstrated. PDT included into the treatment of such patients increases their life expectancy versus the average survival rate in those having palliative therapy.
About the Authors
E. F. Stranadko
Skobelkin Scientific and Practical Center for Laser Medicine FMBA
Russian Federation
Russian Federation
Eugeniy F. Stranadko, MD, Dг. Sci. (med), professor, head of department of laser oncology and photodynamic therapy
121165, Moscow, Studencheskaya str., build. 40
A. I. Lobakov
Moscow Regional Research and Clinical Institute “MONIKI”
Russian Federation
Russian Federation
Alexandre I. Lobakov, MD, professor
129110, Moscow, Schepkina str. 61/2, bldg. 15
V. A. Morokhotov
Moscow Regional Research and Clinical Institute “MONIKI”
Russian Federation
Russian Federation
Vladimir A. Morokhotov, MD, surgeon
129110, Moscow, Schepkina str. 61/2, bldg. 15
M. V. Riabov
Skobelkin Scientific and Practical Center for Laser Medicine FMBA
Russian Federation
Russian Federation
Mikhail V. Riabov, MD, PhD, senior researcher, department of laser oncology and photodynamic therapy
121165, Moscow, Studencheskaya str., build. 40
N. V. Karpov
Moscow Regional Research and Clinical Institute “MONIKI”
Russian Federation
Russian Federation
Nikolai V. Karpov, MD, surgeon
129110, Moscow, Schepkina str. 61/2, bldg. 15
S. V. Morozov
Moscow Regional Research and Clinical Institute “MONIKI”
Russian Federation
Russian Federation
Sergei V. Morozov, MD, professor
129110, Moscow, Schepkina str. 61/2, bldg. 15
V. K. Shubin
Moscow Regional Research and Clinical Institute “MONIKI”
Russian Federation
Russian Federation
Valeiy K. Shubin, MD, surgeon
129110, Moscow, Schepkina str. 61/2, bldg. 15
Y. K. Bogomazov
Moscow Regional Research and Clinical Institute “MONIKI”
Russian Federation
Russian Federation
Yury K. Bogomazov, MD, Cand.Sc.(med), surgeon
129110, Moscow, Schepkina str. 61/2, bldg. 15
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Review
For citations:
Stranadko E.F., Lobakov A.I., Morokhotov V.A., Riabov M.V., Karpov N.V., Morozov S.V., Shubin V.K., Bogomazov Y.K. Photodynamic therapy in the palliative treatment of a stage IV Klatskin tumor. Experimental and Clinical Gastroenterology. 2022;(5):148-153. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-201-5-148-153
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