Gastroenterological manifestations of SARS-CoV-2 and possible consequences of the infection
https://doi.org/10.31146/1682-8658-ecg-200-4-9-13
Abstract
The disease SARS-CoV-2 has various symptoms, including from the gastrointestinal tract. The long-term consequences of this infection require careful study and generalization.
The purpose of the study: to clarify the frequency of gastrointestinal tract lesions in SARS-CoV-2 and its possible consequences. 503 patients with a positive test for COVID-19 were examined. A clinical examination, the study of clinical and biochemical blood tests, the level of fecal calprotectin, computed tomography of the chest, esophagogastroduodenoscopy (EGDS) and fi brocolonoscopy (FCS) with the study of biopsies of the colon mucosa were carried out.
It was found that gastroenterological complaints were present in 58% of patients. Of these, the most common symptom is diarrhea and abdominal pain. Endoscopic examination of the upper gastrointestinal tract revealed most often erosive and ulcerative changes in the mucous membrane of the stomach and duodenum. In some patients, abdominal pain and dyspepsia persisted for 4–6 months after the coronavirus infection, and during FCS erosive changes of the colon mucosa with pronounced infl ammatory infi ltration, crypt abscesses were noted, which indicates the need for medical examination of persons who have undergone SARS CoV-2, with more thorough clarifi cation of gastroenterological complaints and FCS if any.
About the Authors
L. A. Fomina
Tver State Medical University
Russian Federation
Russian Federation
Ludmila A. Fomina, PhD, associate Professor of the Department of Faculty Therapy
4, Sovetskaya St., Tver, 170100
K. E. Nemirov
Сlinical hospital of emergency medical care
Russian Federation
Russian Federation
Konstantin E. Nemirov, Head of the Department of Pathological Anatomy
71, Marshal Konev str. Tver, 170027
E. M. Sacharova
Сlinical hospital of emergency medical care
Russian Federation
Russian Federation
Elena M. Sacharova, pathologist
71, Marshal Konev str. Tver, 170027
References
1. Rodriguez- Morales A.J., Cardona- Ospina J.A., Gutierrez- Ocampo E., Villamizar- Pena R., et al. Clinical, laboratory and imaging features of COVID-19: systematic review and meta-analysis. Treval. Med. Infect. Dis. 2020; 34:1016–1023. doi: 10.1016/j.tmaid.2020.101623
2. Maev I. V., Shpektor A. V., Vasilyeva E. Y., Man churov V. N., Andreev D. N. Novel coronavirus infection COVID-19: extrapulmonary manifestations. Terapevticheskii arkhiv. 2020;92(8):4–11. (in Russ.) doi: 10.26442/00403660.2020.08.000767
3. Wong S. H., Lui R. N., Sung J. J. Covid-19 and the digestive system. J. Gastroenterol. Hepatol. 2020; 35(5): 744–748. doi: 10.1111/jgh.15047
4. Yan R., Zhang Y., Li Y., Хia L., et al. Structural basis for the recognition of SARS-CoV- 2 by full-length human ACE2. Science. 2020; 367(6485): 1444–1448. doi: 10.112/science.abb2762
5. Malik Y. A. Properties of Coronavirus and SARS-CoV-2. Malays J. Pathol. 2020; 42(1): 3–11. doi: 10.1016/j.ijbiomac.2020.06.007
6. Guan W. J., Ni Z. Y., Hu Y., Liang W. H., et al. Clinical Characteristics of Coronavirus Disease 2019 in China. N. Engl. J. Med. 2020; 382(18): 1708–1720. doi: 10.1056/NEJMoa2002032
7. Pan L., Mu M., Yang P., Sun Y., et al. Clinical Characteristics of COVID-19 Patients With DigestiveSymptoms in Hubei, China: A Descriptive, Cross-Sectional, Multicenter Study. Am J Gastroenterol. 2020; 115(5): 766–773. doi: 10.14309/ajg.0000000000000620
8. Wang D., Hu B., Hu C., Zhu F., et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus- infected pneumonia in Wuhan, China. JAMA. 2020; 323(11):1061–1069. doi: 10.1001/jama.2020.1585
9. Liu K., Fang Y. Y., Deng Y., Liu W., et al. Clinical characteristics of novel coronavirus cases in tertiary hospitals in Hubei Province. Chin Med J. 2020; 133(9): 1025–1031. doi: 10.1097/CM9.0000000000000744
10. Mao R., Qiu Y., He J.S, Tan J. Y., et al. Manifestations and prognosis of gastrointestinal and liver involvement in patients with COVID-19: a systematic review and meta-analysis. Lancet Gastroenterol Hepatol. 2020; 5(7): 667–678. doi: 10.1016/S2468–1253(20)30126–6
11. Song Y., Liu P., Shi X. L., Chu J. L., et al. SARS-CoV-2 induced diarrhea as onset symptom in patient with COVID-19. Gut. 2020; 69(6): 1143–1144. doi: 10.1136/gutjnl-2020–320891
12. Jin X., Jiang- Shan L., Hu J. H., Gao J., et al. Epidemiological, clinical and virological characteristics of 74 cases of coronavirus- infected disease 2019 (COVID-19) with gastrointestinal symptoms. Gut. 2020; 69(6): 1002–1009. doi: 10.1136/gutjnl-2020–320926
13. Vanella G., Capurso G., Burti C., Fanti L., et al. Gastrointestinal mucosal damage in patients with COVID-19 undergoing endoscopy: an international multicentre study BMJ Open Gastroenterol. 2021; 8(1): e000578. doi: 10.1136/bmjgast-2020–000578
Review
For citations:
Fomina L.A., Nemirov K.E., Sacharova E.M. Gastroenterological manifestations of SARS-CoV-2 and possible consequences of the infection. Experimental and Clinical Gastroenterology. 2022;(4):9-13. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-200-4-9-13
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