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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nogr</journal-id><journal-title-group><journal-title xml:lang="ru">Экспериментальная и клиническая гастроэнтерология</journal-title><trans-title-group xml:lang="en"><trans-title>Experimental and Clinical Gastroenterology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-8658</issn><publisher><publisher-name>«Global Media Technologies»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31146/1682-8658-ecg-200-4-9-13</article-id><article-id custom-type="elpub" pub-id-type="custom">nogr-1929</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКАЯ ГАСТРОЭНТЕРОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL GASTROENTEROLOGY</subject></subj-group></article-categories><title-group><article-title>Гастроэнтерологические проявления SARS-CОV-2 и возможные последствия перенесенной инфекции</article-title><trans-title-group xml:lang="en"><trans-title>Gastroenterological manifestations of SARS-CoV-2 and possible consequences of the infection</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0461-2691</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Фомина</surname><given-names>Л. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Fomina</surname><given-names>L. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Фомина Людмила Артуровна, к. м. н., доцент кафедры факультетской терапии</p><p>170100, Тверь, ул. Советская, д. 4</p></bio><bio xml:lang="en"><p>Ludmila A. Fomina, PhD, associate Professor of the Department of Faculty Therapy</p><p>4, Sovetskaya St., Tver, 170100</p></bio><email xlink:type="simple">Ludmifom@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Немиров</surname><given-names>К. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Nemirov</surname><given-names>K. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Немиров Константин Евгеньевич, заведующий отделением патологической анатомии</p><p>170027, Тверь, ул. Маршала Конева, д. 71</p></bio><bio xml:lang="en"><p>Konstantin E. Nemirov, Head of the Department of Pathological Anatomy</p><p>71, Marshal Konev str. Tver, 170027</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сахарова</surname><given-names>Е. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Sacharova</surname><given-names>E. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сахарова Елена Михайловна, врач-патологоанатом отделения патологической анатомии</p><p>170027, Тверь, ул. Маршала Конева, д. 71</p></bio><bio xml:lang="en"><p>Elena M. Sacharova, pathologist</p><p>71, Marshal Konev str. Tver, 170027</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное образовательное учреждение высшего образования «Тверской государственный медицинский университет» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Tver State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Государственное бюджетное учреждение здравоохранения «Клиническая больница скорой медицинской помощи»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Сlinical hospital of emergency medical care</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>03</day><month>10</month><year>2022</year></pub-date><volume>0</volume><issue>4</issue><fpage>9</fpage><lpage>13</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Фомина Л.А., Немиров К.Е., Сахарова Е.М., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Фомина Л.А., Немиров К.Е., Сахарова Е.М.</copyright-holder><copyright-holder xml:lang="en">Fomina L.A., Nemirov K.E., Sacharova E.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.nogr.org/jour/article/view/1929">https://www.nogr.org/jour/article/view/1929</self-uri><abstract><p>Заболевание SARS-CoV-2 имеет различную симптоматику, в том числе и со стороны желудочно- кишечного тракта.</p><p>Отдаленные последствия данной инфекции требуют тщательного изучения и обобщения.</p><p>Цель исследования: уточнить частоту встречаемости поражений желудочно- кишечного тракта при SARS-CoV-2 и ее возможные последствия.</p><p>Обследовано 503 пациента с положительным ПЦР тестом на COVID-19. Проводилось клиническое обследование, изучение клинического и биохимического анализов крови, уровня фекального кальпротектина, компьютерная томография грудной клетки, эзофагогастродуоденоскопия (ЭГДС) и фиброколоноскопия (ФКС) с изучением биоптатов слизистой оболочки толстой кишки. </p><p>Установлено, что гастроэнтерологические жалобы присутствовали у 58% пациентов. Из них самый частый симптом — диарея и абдоминальные боли. Эндоскопическое обследование верхних отделов желудочно- кишечного тракта выявляло чаще всего эрозивно- язвенные изменения слизистой оболочки желудка и двенадцатиперстной кишки. У некоторых больных абдоминальный болевой и диспепсический синдромы сохранялись в течении 4–6 месяцев после перенесенной коронавирусной инфекции, а при фиброколоноскопии (ФКС) отмечались эрозивные изменения слизистой оболочки толстой кишки с выраженной воспалительной инфильтрацией, крипт-абсцессы, что указывает на необходимость диспансеризацию лиц, перенесших SARS CoV-2, с более тщательным выяснением гастроэнтерологичесих жалоб и проведением ФКС при их наличии.</p></abstract><trans-abstract xml:lang="en"><p>The disease SARS-CoV-2 has various symptoms, including from the gastrointestinal tract. The long-term consequences of this infection require careful study and generalization.</p><p>The purpose of the study: to clarify the frequency of gastrointestinal tract lesions in SARS-CoV-2 and its possible consequences. 503 patients with a positive test for COVID-19 were examined. A clinical examination, the study of clinical and biochemical blood tests, the level of fecal calprotectin, computed tomography of the chest, esophagogastroduodenoscopy (EGDS) and fi brocolonoscopy (FCS) with the study of biopsies of the colon mucosa were carried out.</p><p>It was found that gastroenterological complaints were present in 58% of patients. Of these, the most common symptom is diarrhea and abdominal pain. Endoscopic examination of the upper gastrointestinal tract revealed most often erosive and ulcerative changes in the mucous membrane of the stomach and duodenum. In some patients, abdominal pain and dyspepsia persisted for 4–6 months after the coronavirus infection, and during FCS erosive changes of the colon mucosa with pronounced infl ammatory infi ltration, crypt abscesses were noted, which indicates the need for medical examination of persons who have undergone SARS CoV-2, with more thorough clarifi cation of gastroenterological complaints and FCS if any.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>SARS-CoV-2</kwd><kwd>диарея</kwd><kwd>абдоминальная боль</kwd><kwd>острые язвы</kwd><kwd>эрозии</kwd></kwd-group><kwd-group xml:lang="en"><kwd>SARS-CoV-2</kwd><kwd>diarrhea</kwd><kwd>abdominal pain</kwd><kwd>acute ulcers</kwd><kwd>erosions</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Rodriguez- Morales A.J., Cardona- Ospina J.A., Gutierrez- Ocampo E., Villamizar- Pena R., et al. 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