Clinical significance of studying the genetic polymorphism of adhesion factors in Helicobacter pylori-associated diseases
https://doi.org/10.31146/1682-8658-ecg-197-1-18-23
Abstract
The aim of the work was to study the clinical significance of the genetic polymorphism of the adhesion factor - the genetic locus rs602662 FUT2 in Helicobacter pylori-associated diseases. Methods: The study included 91 patients. The study for the presence of the polymorphic locus rs602662 of the FUT2 gene was carried out by the standard TaqMan PCR method on a “Real-Time CFX96 Touch” amplifier. The duration of the study was 6 months. Results: When assessing the contribution of the genotype of the rs602662 locus of the FUT2 gene as a risk factor for the occurrence of clinical manifestations in H. pylori infection, it was found that the A allele has a protective effect on the occurrence of clinical symptoms of dyspepsia. The odds ratio (OR) for allele “A” carriers (genotypes A/A and G/A versus G/G) to have clinical symptoms with a positive H. pylori status was 0.175 (CI=[0.049-0.625] chi2=7.79 p=0.0053). Conclusion. As a result of the study, it was revealed that the carriage of the “A” allele has a significant associative relationship with the absence of clinical symptoms in patients with H. pylori infection 0.175 (C.I.= [0.049-0.625] chi2=7.79 p=0.0053).
About the Authors
G. I. Lifshits
Novosibirsk State University; Institute of chemical, Institute of Chemical Biology and Fundamental Medicine of the SB RAS
Russian Federation
Russian Federation
E. V. Shrayner
Novosibirsk State University; Institute of chemical, Institute of Chemical Biology and Fundamental Medicine of the SB RAS
Russian Federation
Russian Federation
N. V. Kokh
Novosibirsk State University; Institute of chemical, Institute of Chemical Biology and Fundamental Medicine of the SB RAS
Russian Federation
Russian Federation
E. N. Voronina
Research Clinical Institute of Childhood of the Moscow Region
Russian Federation
Russian Federation
A. I. Khavkin
Research Clinical Institute of Childhood of the Moscow Region; Belgorod State Research University
Russian Federation
Russian Federation
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Review
For citations:
Lifshits G.I., Shrayner E.V., Kokh N.V., Voronina E.N., Khavkin A.I. Clinical significance of studying the genetic polymorphism of adhesion factors in Helicobacter pylori-associated diseases. Experimental and Clinical Gastroenterology. 2022;(1):18-23. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-197-1-18-23
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