Relationship of the mucin-degrading bacterium Akkermansia muciniphila with colorectal cancer
https://doi.org/10.31146/1682-8658-ecg-178-6-158-165
Abstract
Colorectal cancer is a disease that is far from the last place in the morbidity statistics in the Russian Federation and in the world. Along with well-known risk factors for the development of this pathology, some representatives of the intestinal microbiota are possible to participate in this process. Some studies suggest that Akkermansia muciniphila, a mucin-degrading bacterium, is associated with colorectal cancer development, but other studies cast doubt on this statement. In this review, we describe a series of studies devoted to determining the dependence of colorectal cancer on the amount of A. muciniphila, the relationship of this bacterium with inflammation development as a predictor of oncogenesis, the influence of other representatives of the intestinal microbiota on its function, and also describe one of the possible mechanisms linking the mucin-degraging ability of this bacterium with the development of oncogenesis.
About the Authors
A. M. Karamzin
I. M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation
Russian Federation
Cand. of Biol. Sci., Associate Professor of the Department of Microbiology, Virology and Immunology,
Moscow
A. V. Ropot
I. M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation
Russian Federation
student of the International school “Medicine of the Future”,
Moscow
R. E. Boshian
I. M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation
Russian Federation
Cand. of Med. Sci., Associate Professor of the Department of Microbiology, Virology and Immunology,
Moscow
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Review
For citations:
Karamzin A.M., Ropot A.V., Boshian R.E. Relationship of the mucin-degrading bacterium Akkermansia muciniphila with colorectal cancer. Experimental and Clinical Gastroenterology. 2020;(6):158-165. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-178-6-158-165
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