Clinical and genetic feature sof duodenal ulcer
https://doi.org/10.31146/1682-8658-ecg-169-9-45-49
Abstract
Purpose of the study. To evaluate the clinical and genetic picture of patients with duodenal ulcer.
Materials and research methods. A total of 139 patients with duodenal ulcer were examined. Of these, hereditary predisposition groups (n = 102) and without it (n = 129) were selected, which were examined according to standards, including the analysis of polymorphic variants of IL8 genes (–251T>A; rs4073), IL10 (–627С> A; rs1800872), TNFA (–308G> A; rs1800629), the gene for antagonist to the IL1 receptor (IL1RN (VNTR); rs71941886)) by PCR, investigated the psychological status.
Results. Patients with a genetic predisposition were found to have the first blood group, non-compliance with the diet, threshold resistance to stress, lack of family life, the presence of duodeno-gastric reflux, gross deformity of the bulb, increased acidity, men had more frequent night work, smoking, alcohol intake, medium-specific education. In patients, the rs1800872 * AA genotype and the rs1800872 * A allele of the IL10 gene (–627С> A; rs1800872) are markers of the development of duodenal ulcer.
Conclusion. Conducting genetic studies of individuals along with clinical examinations contributes to an integrated approach in the management of individuals with duodenal ulcer.
About the Authors
L. V. Volevach
FSBEI HE Bashkir State Medical University of the Ministry of Health of Russia
Russian Federation
Larisa V. Volevach, Department of Polyclinic Therapy with an ICPE course, Head of Department, Professor, Doctor of Medical Sciences, 450008, Ufa, Lenin str., 3, Russia
Russian Federation
Larisa V. Volevach, Department of Polyclinic Therapy with an ICPE course, Head of Department, Professor, Doctor of Medical Sciences, 450008, Ufa, Lenin str., 3, Russia
A. S. Sarsenbayeva
FSBEI HE South Ural State Medical University of the Ministry of Health of Russia
Russian Federation
Aiman S. Sarsenbayeva, Dean of the ICPE, Department of Therapy ICPE, Professor, Doctor of Medical Sciences, 454080, Chelyabinsk, Lenin Ave., 76, Russia
Russian Federation
Aiman S. Sarsenbayeva, Dean of the ICPE, Department of Therapy ICPE, Professor, Doctor of Medical Sciences, 454080, Chelyabinsk, Lenin Ave., 76, Russia
L. V. Gabbasova
FSBEI HE Bashkir State Medical University of the Ministry of Health of Russia
Russian Federation
Liliya V. Gabbasova, Department of Polyclinic Therapy with an ICPE course, Associate Professor, Candidate of Medical Sciences, 450008, Ufa, Lenin str., 3, Russia
Russian Federation
Liliya V. Gabbasova, Department of Polyclinic Therapy with an ICPE course, Associate Professor, Candidate of Medical Sciences, 450008, Ufa, Lenin str., 3, Russia
A. Ya. Kryukova
FSBEI HE Bashkir State Medical University of the Ministry of Health of Russia
Russian Federation
Antonina Ya. Kryukova, Department of Polyclinic Therapy with an ICPE course, Professor, Doctor of Medical Sciences, 450008, Ufa, Lenin str., 3, Russia
Russian Federation
Antonina Ya. Kryukova, Department of Polyclinic Therapy with an ICPE course, Professor, Doctor of Medical Sciences, 450008, Ufa, Lenin str., 3, Russia
A. Kh. Nurgaliyeva
FSBEI HE Bashkir State University
Russian Federation
Alfi ya Kh. Nurgaliyeva, Department of Genetics and Fundamental Medicine, Associate Professor, Candidate of Biological Sciences, 450076, Ufa, Z. Validi str., 32, Russia
Russian Federation
Alfi ya Kh. Nurgaliyeva, Department of Genetics and Fundamental Medicine, Associate Professor, Candidate of Biological Sciences, 450076, Ufa, Z. Validi str., 32, Russia
E. K. Khusnutdinova
FSBEI HE Bashkir State University
Russian Federation
Russian Federation
Elza K. Khusnutdinova, Department of Genetics and Fundamental Medicine, Head of Department, Professor, Doctor
of Biological Sciences, 450076, Ufa, Z. Validi str., 32, Russia
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Review
For citations:
Volevach L.V., Sarsenbayeva A.S., Gabbasova L.V., Kryukova A.Ya., Nurgaliyeva A.Kh., Khusnutdinova E.K. Clinical and genetic feature sof duodenal ulcer. Experimental and Clinical Gastroenterology. 2019;(9):45-49. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-169-9-45-49
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