Clinical and epidemiological characteristics and outcomes of inflammatory bowel diseases according to 8-year follow-up in a cohort of patients in the North-West region

I. V. Gubonina; V. B. Grinevich; E. I. Tkachenko; N. B. Volga; O. S. Sharap; M. V. Poluektov; A. I. Zherdev; N. A. Plisikova; V. A. Barnakova; I. V. Potapova; T. V. Kolodin; Ya. V. Starodubcev; M. M. Araphanova; N. S. Gubonina; V. I. Kuvakin

doi:10.31146/1682-8658-ecg-172-12-24-33

Clinical and epidemiological characteristics and outcomes of inflammatory bowel diseases according to 8-year follow-up in a cohort of patients in the North-West region

I. V. Gubonina, V. B. Grinevich, E. I. Tkachenko, N. B. Volga, O. S. Sharap, M. V. Poluektov, A. I. Zherdev, N. A. Plisikova, V. A. Barnakova, I. V. Potapova, T. V. Kolodin, Ya. V. Starodubcev, M. M. Araphanova, N. S. Gubonina, V. I. Kuvakin

https://doi.org/10.31146/1682-8658-ecg-172-12-24-33

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Abstract

The 8-year observation data of patients with ulcerative colitis and Crohn’s disease in the North West region are presented in the article. The patients were observed in the scientific and clinical center of Military Medical academy named after S. M. Kirov, specialized in the inflammatory bowel diseases (IBD). The aim of study is to assess the gender, age and clinical characteristics of patients with inflammatory bowel diseases, epidemiological features: factors of employment and place of residence, to study the outcomes of ulcerative colitis (UC) and Crohn’s disease (CD). Materials and methods. Retrospective analysis of 485 patient’s medical charts (373 patients with ulcerative colitis and 112 patients with Crohn’s disease) in the period from 2010 to 2018 was performed. Results. The onset of inflammatory bowel diseases is most common in the age group up to 40 years. The duration of the period before the diagnosis of ulcerative colitis and Crohn’s disease averaged 2.3 years. In UC the most frequent localization of the pathological process was left-side colon (51%), in CD - terminal ileitis (29%) and ileocolitis (27%). The anemia was the most frequent complication in both form of IBD, but structuring and penetrating complications were characteristic of CD. The most of patients (80.6%) had recurrent or continuous course of IBD. Small proportion of patients (19.4%) had sustained remission throughout the follow-up period. The frequency of surgical interventions in CD (27.6%) was comparable with the registers of the European study groups of IBD. In contrast, the frequency of colectomy in UC was significantly lower (0.8%) than in the published data of European countries, due to the predominance of mild and moderate forms of UC in the observed cohort. Mortality of patients with IBD was higher than in the General population of St. Petersburg due to the contribution of mortality from complicated forms of IBD (15.7%), while the structure of other causes of death was comparable to the General population

Keywords

воспалительные заболевания кишечника, язвенный колит, болезнь Крона, эпидемиология, Северо-Западный регион, терапия, хирургия, смертность, исходы, inflammatory bowel disease, ulcerative colitis, Crohn’s disease, epidemiology, North-West region, therapy, surgery, mortality, outcomes

About the Authors

I. V. Gubonina

Federal state budgetary military educational institution of high professional education “Military Medical Academy named after S. M. Kirov” of the Ministry of defense of the Russian Federation
Russian Federation

V. B. Grinevich

E. I. Tkachenko

N. B. Volga

O. S. Sharap

M. V. Poluektov

A. I. Zherdev

N. A. Plisikova

V. A. Barnakova

I. V. Potapova

T. V. Kolodin

Ya. V. Starodubcev

M. M. Araphanova

N. S. Gubonina

V. I. Kuvakin

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Gubonina I.V., Grinevich V.B., Tkachenko E.I., Volga N.B., Sharap O.S., Poluektov M.V., Zherdev A.I., Plisikova N.A., Barnakova V.A., Potapova I.V., Kolodin T.V., Starodubcev Ya.V., Araphanova M.M., Gubonina N.S., Kuvakin V.I. Clinical and epidemiological characteristics and outcomes of inflammatory bowel diseases according to 8-year follow-up in a cohort of patients in the North-West region. Experimental and Clinical Gastroenterology. 2019;(12):24-33. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-172-12-24-33

This work is licensed under a Creative Commons Attribution 4.0 License.

ISSN 1682-8658 (Print)

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Experimental and Clinical Gastroenterology

Clinical and epidemiological characteristics and outcomes of inflammatory bowel diseases according to 8-year follow-up in a cohort of patients in the North-West region

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Abstract

Keywords

About the Authors

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