Influence of pathogenicity factors of Helicobacter pylori (Cag A and Vac A) on precancerous changes of gastric mucosa in patients with chronic gastritis
https://doi.org/10.31146/1682-8658-ecg-165-5-67-71
Abstract
The aim: to assess the influence of HP pathogenicity factors (Cag A, Vac A) on atrophy, intestinal metaplasia, dysplasia of the gastric mucosa in patients with chronic gastritis (CG) associated with HP. Materials and methods: 64 patients (46 men, 18 women) with signs of chronic gastritis aged 30 to 60 years (mean age 43,5±8,4 years) were examined (fibrogastroscopy and histological examination of biopsies). Results: a direct correlation between the presence of HP pathogenicity factors (Cag A, Vac A) and the development of atrophic changes in the gastric mucosa, as well as the degree of chronization of the process and the activity of inflammation of the gastric mucosa was revealed in the groups of patients.
About the Authors
I. L. Pegasheva
Federal state budgetary military educational institution of higher education “S. M. Kirov military medical Academy” of the Ministry of defence of the Russian Federation
Russian Federation
Russian Federation
I. M. Pavlovich
Federal state budgetary military educational institution of higher education “S. M. Kirov military medical Academy” of the Ministry of defence of the Russian Federation
Russian Federation
Russian Federation
A. V. Gordienco
Federal state budgetary military educational institution of higher education “S. M. Kirov military medical Academy” of the Ministry of defence of the Russian Federation
Russian Federation
Russian Federation
V. S. Chyrskiy
Federal state budgetary military educational institution of higher education “S. M. Kirov military medical Academy” of the Ministry of defence of the Russian Federation
Russian Federation
Russian Federation
A. A. Erokhina
Federal state budgetary military educational institution of higher education “S. M. Kirov military medical Academy” of the Ministry of defence of the Russian Federation
Russian Federation
Russian Federation
A. V. Swarwal
Federal budgetary institution of science “St. Petersburg research Institute of epidemiology and Microbiology. Pasteur” of the Federal service for supervision of consumer rights protection and human welfare
Russian Federation
Russian Federation
Review
For citations:
Pegasheva I.L., Pavlovich I.M., Gordienco A.V., Chyrskiy V.S., Erokhina A.A., Swarwal A.V. Influence of pathogenicity factors of Helicobacter pylori (Cag A and Vac A) on precancerous changes of gastric mucosa in patients with chronic gastritis. Experimental and Clinical Gastroenterology. 2019;(5):67-71. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-165-5-67-71
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