Morphofunctional state of stomach in patients with haematological malignancies in the period of clinical and haematological remission

Purpose of the study. To study the morphofunctional state of the stomach in patients with hemoblastosis in the period of clinical-hematologic remission (GSR). Materials and methods. 164 patients with lymphomas were examined. The average number of courses of polychemotherapy (PCT) is 9.4 + 0.9, the average duration of remission is 66.47 + 9.26 months. Comparison group - 72 patients with chronic HP-associated gastritis without hematologic disease. Results. During the period of GSR, the frequency of symptoms of gastric dyspepsia increased, with the pain syndrome being negligible, the frequency of pyloric Helicobacter (HP) detection decreased significantly. The relationship of HP and dysplasia of the epithelium of the gastric mucosa was noted, which was detected much more often than in patients with chronic HP-associated gastritis without hematological pathology (OR = 319, (95% CI- (20.06-5073.5, p <0.0001), which suggests more a high risk of developing gastric cancer in patients with hemoblastosis in the GSR period. Сonclusion. Morphological changes in the stomach, including ulcerogenic and procancerogenic (erosion, atrophy, dysplasia) in patients with hematological diseases in the period of clinical and hematological remission are more frequent and expressed more than before treatment.

желудок, морфология, гемобластозы, цитостатическая терапия, клинико-гематологическая ремиссия, stomach, morphology, hemoblastoses, cytostatic therapy, clinical-hematological remission