Gastrointestinal symptoms in patients with gilt-patient disease in the dynamics of 10-year observation

Study of the conducted studies with the participation of children and adolescents during the 10-year observation of patients with cholelithiasis (CL). Materials and methods: The work is a fragment of a 10-year follow-up of patients with CL. Two groups were formed: the 1st group (1) (n = 113) patients with cholecystectomy who underwent cholecystectomy (CE) and were prospectively observed for 10 years; 2-nd- (2) (n = 92) - unoperated patients with SCI, a prescription of at least 10 years, the symptoms of which were retrospectively analyzed. Results: Heartburn frequency for the 10-year period increased in the 1st group by 47.8%, in the group (2) by 22.8% (p = 0.005). In the group (1), with the initially symptomatic course, the maximum increased - by 66.3% (p <0.001) and by 45.8% with the initially asymptomatic flow (p = 0.001). In the group (2), in patients with initially asymptomatic course increased by 40% (p = 0.003). The symptom of «bitterness in the mouth» began to be detected more often in the first group by 22.1% (p <0.001), almost independently of the original version of the flow. The frequency of the symptom of «fatty food intolerance» (NFI) increased in the 2 nd group by 15.2% (p = 0.006), mainly due to the group with the initially symptomatic course. The frequency of diarrhea in the 1st group increased by 37.3% (p = 0.046), especially significant in the group with baseline asymptomatic course 33.3% (p = 0.005).The frequency of constipation increased in the 1st group by 25.6% (p <0.001), predominantly in the symptomatic group with a 27% decrease (p <0.001).The incidence of bitter mouth symptoms, diarrhea, constipation in group (2) has changed statistically insignificantly. Conclusions: During the 10-year follow-up of patients with CL, the frequency of symptoms increased, especially significantly: heartburn, bitterness in the mouth, diarrhea, constipation in patients after CE. Symptoms of heartburn and constipation began to occur more often in groups with the initially symptomatic course. The symptom of NFI began to be detected more often in the group of unoperated patients with CL.

желчнокаменная болезнь, последствия холецистэктомии, постхолецистэктомический синдром, изжога, «горечь во рту», диарея, запор, гастроинтестинальные симптомы, cholelithiasis, postcholecystectomy syndrome, gastrointestinal symptoms after surgical treatment of gallstone disease