Morphological changes in the liver in rats for liver diseases and decompensated type 2 diabetes after performing various types of bariatric operations
https://doi.org/10.31146/1682-8658-ecg-168-8-72-76
Abstract
Bariatric surgery is widely used for weight regression in patients with obesity and metabolic syndrome, and improves course of non-alcoholic fatty liver disease (NAFLD) in obese patients. However, there are very little researches devoted to the evaluation of morphological liver’s changing after bariatric surgeries on decompensated T2DM without severe obesity. The aim of the study was to evaluate the effect of various types of bariatric operations on the morphological changes in the liver of rats with severe, decompensated form of diabetes. The study shows that the implementation of bariatric surgery of sleeve gastrectomy contributes to the regression of liver steatosis. The obtained data can be the basis for optimizing approaches when using bariatric operations in the treatment of patients with NAFLD.
Keywords
экспериментальные животные,
неалкогольная жировая болезнь печени,
неалкогольный стеатоз печени,
сахарный диабет 2 типа,
ожирение,
бариатрическая хирургия,
experimental animal,
Non-alcoholic fatty liver disease,
non-alcoholic steatosis of the liver,
type 2 diabetes mellitus,
obesity,
bariatric surgery
About the Authors
O. V. Kornyushin
Federal State Budgetary Institution «V. A. Almazov Federal North-West Medical Research Centre» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Ya. G. Toropova
Federal State Budgetary Institution «V. A. Almazov Federal North-West Medical Research Centre» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
O. M. Berko
Pavlov First Saint Petersburg State Medical University of the Russian Federation
Russian Federation
Russian Federation
I. A. Zelinskaya
Federal State Budgetary Institution «V. A. Almazov Federal North-West Medical Research Centre» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
I. N. Danilov
Federal State Budgetary Institution «V. A. Almazov Federal North-West Medical Research Centre» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
V. A. Zinserling
Federal State Budgetary Institution «V. A. Almazov Federal North-West Medical Research Centre» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
A. E. Neimark
Federal State Budgetary Institution «V. A. Almazov Federal North-West Medical Research Centre» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Review
For citations:
Kornyushin O.V., Toropova Ya.G., Berko O.M., Zelinskaya I.A., Danilov I.N., Zinserling V.A., Neimark A.E. Morphological changes in the liver in rats for liver diseases and decompensated type 2 diabetes after performing various types of bariatric operations. Experimental and Clinical Gastroenterology. 2019;(8):72-76. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-168-8-72-76
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