Polymorphysm of tumor supressor gene tp53 among healthy donors and patients with rectal cancer

Abstract

The aim was to investigate the prevalence of genetic variants of marker rs1042522 (Arg72Pro) of TP53 among individuals without cancer and patients with colon cancer. Materials and methods. Using allele specific PCR we performed genotyping of rs1042522 marker with subsequent comparing of alleles and genotypes frequencies in two studied groups: the comparison group (n=119) and the group of patients with rectal cancer (n=105). Results. Proportion of the minor allele Pro with the expected pathological effect in the comparison group was 26,9%, and among patients with rectal cancer - 26,7%. The frequency of the Pro/Pro genotype in the two groups was 6,7% and 5,7%, respectively. The distinction in indicators was not statistically significant.