New approach to the estimation of a clinical flow in patients with ulceratıve colitis and Crohn's disease

Aim: to create a system for monitoring the condition of patients with inflammatory bowel disease (IBD). Subjects and methods: In the period from August 2015 to December 2018, 246 patients with IBD were examined at the clinical base of the Department of Therapy Azerbaijan State Advanced Training Institute for doctors named after A.ALIYEV, the Department of Invasive Diagnostics and Treatment of the National Center of Oncology, Memorial Klinika Medical Center. The content of homocysteine, highly sensitive C-reactive protein (h/s CRP), vitamin D and the level of platelets in the blood, albumin in the urine, and calprotectin in the feces were determined in all subjects. Patients were retested if necessary (426 in total) Results: In the general group of patients with IBD, of the 426 studies conducted in 369 (86.6%) cases, there was an increased content of homocysteine in the blood, in 405 (95.0%) - the level of h/s CRP, in 322 (75.5%) - thrombocytosis, in 411 (96.4%) - a decrease in the content of vitamin D, in 308 (72.3%) albumin was detected in the urine, and in 411 (96.4%) - an increased content of calprotectin was detected in the feces. When analyzing the identification of each of these indicators separately in the UC and CD groups, no difference was found (p > 0.05). A correlation was found between some indicators of endothelial dysfunction and the severity of the clinical course in patients with inflammatory bowel diseases. The proposed new approach to assessing the clinical status of patients with IBD, with the established diagnosis, does not resort to repeated costly studies and obtain real-time results that make it possible to assess the severity of the patient’s condition.

язвенный колит, болезнь Крона, воспалительные заболевания кишечника, эндотелтальная дисфункция, степень тяжести, ulcerative colitis, Crohn’s disease, inflammatory bowel disease, endothelial dysfunction, severity