The experience of the fecal microbiota transplantation in a patient with clostridial infection

Abstract

In recent decades, against the background of widespread and, often, unfounded antibiotic therapy, an increase in Clostridium difficile infection (CDI) due to hypervirulent strains has been observed. According to international CDI treatment protocols, metronidazole and vancomycin are starting therapy for patients with newly diagnosed infections, even though the likelihood of a relapse is about 65%. In addition, the increased interest in CDI is associated with the need to develop and use alternative strategies aimed at preventing and increasing the effectiveness of treatment. In this regard, we first transplanted fecal microflora for this group of patients in Russia. This alternative method of treatment removes the spores of C. difficile, replenishes the normal intestinal flora, reduces the level of vegetative forms of C. difficile in the intestines, and supports the patient’s own immune response.