Endogenous intoxication in mechanical joundice and the possibility of its pathogenetic correction

Abstract

Purpose of the study. To assess the severity of endogenous intoxication in mechanical jaundice and to study the detoxification effect of the ozonized saline solution. Materials and methods. There were studied the results of surgical treatment of 76 patients with mechanical jaundice, divided into 2 groups. Patients in the group 1 (n = 40) underwent conventional treatment. 36 patients of the 2nd group were treated with ozonized saline solution. The following were determined: aspartate aminotransferase (ASAT), alanine aminotransferase (ALAT); common and direct bilirubin, average weight molecules (AMM), malonicdialdehyde (MDA), catalase, creatinine and urea concentration in plasma. Results. On the 15th day of the postoperative period, the levels of ALAT, AMM, MDA, creatinine, urea were decreased in patients of group 1 by 33, 36, 38, 30 and 38% respectively, the level of catalase increased by 32%. In patients of the 2nd group, the levels of ALAT, AMM, MDA, creatinine and urea decreased by 59, 56, 61, 35, 55%, whereas the catalase level increased by 65%. The conclusion. The therapy with ozonized saline solution promotes the decrease of the level of endogenous intoxication due to more pronounced activation of antioxidant system with a decrease of the level of free radical oxidation and of destructive processes in the liver.