Structural and functional features of the liver in patients with non-alcoholic fatty liver disease, depending on the severity of obesity

The aim of this study was assessment of the structural and functional state of the liver in patients with non-alcoholic fatty liver disease (NAFLD) with excessive body weight and obesity of I - II degree. The study included 120 patients with NAFLD (45 to 65 years old) with diabetes mellitus type 2. Depending on the body mass index, patients were divided into four groups, comparable by sex, age, severity of chronic heart failure (myocardial infarction from 6 to 12 months earlier). Patients were examined by standard clinical and anthropometric methods, assessment of visceral obesity with bioimpedanceometry and a calculation method. Level of functional status and markers of hepatocyte damage were studied by the biochemical blood test according to standard laboratory methods. Structural state of the liver was evaluated according to ultrasound data and with calculated indices of steatosis and fibrosis of the liver. The results of the study showed that as the body mass index increases, a significantly higher incidence of hyperfermentemia transaminases and gamma glutamyltranspeptidase is determined. The level of visceral adiposity and fatty tissue dysfunction in patients with NAFLD significantly correlated with the severity of cytolysis and cholestasis, decline of bilirubinemia. Patients with heavier structural changes in the liver, both from ultrasound data and from computational methods, are prevailed among patients with obesity. In conclusion: an increase of the severity of obesity, including visceral obesity, the severity of visceral fat dysfunction in patients with NAFLD is accompanied by an increase in structural and functional disorders in the liver.

неалкогольная жировая болезнь печени, ожирение, дисфункция жировой ткани, структурно-функциональное состояние печени, non-alcoholic fatty liver disease, obesity, fat dysfunction, structural and functional state of the liver