DYNAMICS OF INDICATORS OF PROSTAGLANDINS IN PATIENTS WITH LIVER CIRRHOSIS WITH ASCITES AND HEPATORENAL SYNDROME

Abstract

The group under study consisted of 387 patients with LC. The levels of prostaglandins (Pg) I₂ and F_2α, their dynamics in patients with LC were studied depending on the differentiated method of correction of ascites and (HRS) in these patients. In all patients with LC a statistically significant increase in serum levels of Pg I₂ and F_2α was observed. Our studies indicate the presence of regularity in the dynamics of serum Pg I₂ levels in patients with ascites and HRS with LC, namely: in patients with LC and ascites class B, an increase in the level of Pg I₂ was observed, which tends to normalize in class C in these patients, whereas in patients LC and HRS class B level of Pg I₂ in the blood serum is within normal range, and in class C in these patients, is decreased in 2-2.5 times than normal. 1. In patients with LC, ascites and HRS there is a violation of serum prostaglandins levels, namely, an increase in Pg F_2α, and decrease in Pg I₂, which indicates the formation of refractory ascites and HRS in these patients. 2. An effective method of correction prostaglandins levels in patients with LC is the use of symbiotic and combined drugs “Gepadif” in the early stages of ascites formation, which contributes to the prevention of resistance to treatment of ascites and HRS.