NEURON SPECIFIC ENOLASE IN CHRONIC GASTRODUODENITIS, ASSOCIIROVAL WITH HЕLICOBACTER PYLORI INFECTION IN CHILDREN AND ADOLESCENTS

Abstract

The purpose of this study was to assess changes in the level of neuron specific enolase (NSE) in boys and girls with chronic gastroduodenitis (CGD), taking into account the severity of the disease and the presence of Helicobacter pylori infection. Material and methods: we examined 73 children with CGD. The first group (32 people) included children with erosive gastroduodenitis of them with a positive examination result on the HP-infection and 16 patients (subgroup 1) and 16 negative tests for HР infection (subgroup 2). Group II included 41 children with superficial gastroduodenitis, 14 of them with a positive result of the survey on HР (subgroup 1) and 27 with negative tests for HР (subgroup 2). The control group (CG) consisted of 28 children I-II health groups. In the diagnosis of the disease was used endoscopic and morphological methods; urease, microscopy, molecular biological and serological tests were carried out for the verification of HР. Results: the analysis of the dynamics of the level of NSE showed high values of this index in boys group II subgroup 2 in comparison with children I group 2 subgroups (p≤0,01). High rates of NSE were detected in boys group I subgroup 1 and 2 group II subgroup compared to CG (p≤0,05, p≤0,01). The girls are a group 1 subgroup, the values of NSE above the level I group 2 subgroup, and CG (p≤0,05; p≤0,01). The girls of group II subgroup 2 of index of NSE is higher compared to patients of subgroup 1 and CG (p≤0,01; p≤0,01). The level of NSE in girls group II subgroup 1 were also higher than values of this index in CG (p≤0,05). The results indicate a possible role of NSE in the development of severe forms of the disease in the absence of pathogenic effects of HP and do not exclude a certain link with the function of sex hormones