HELICOBACTER PYLORI BIOFILM IN VITRO AND IN VIVO
Abstract
Using scanning electron microscopy, the ability of reference and freshly isolated Helicobacter pylori strains to form biofilm under cultivation on abiotic surfaces and in natural conditions was studied. It was shown that both types of strains were capable of biofilm formation in vitro, although reference strains synthesized less pronounced exocellular matrix and flagella than freshly isolated strains. Bio-film also was detected in specimens of antral mucosa under duodenal ulcer. Most often Helicobacter pylori biofilms were detected near the mouths of the gastric glands. The structure of matrix surface of such biofilms looked inhomogeneous in different parts of the epithelial layer.
About the Authors
V. G. Zhukhovitsky
Gamaleya Federal Research Centre for Microbiology and Immunology of the Ministry of Public Health; Botkin Hospital of Moscow Department of Public Health; Sechenov the First Moscow Medical University of the Ministry of Public Health
Russian Federation
Russian Federation
T. A. Smirnova
Gamaleya Federal Research Centre for Microbiology and Immunology of the Ministry of Public Health
Russian Federation
Russian Federation
N. V. Shevlyagina
Gamaleya Federal Research Centre for Microbiology and Immunology of the Ministry of Public Health
Russian Federation
Russian Federation
I. Yu. Korzheva
Botkin Hospital of Moscow Department of Public Health
Russian Federation
Russian Federation
L. V. Didenko
Gamaleya Federal Research Centre for Microbiology and Immunology of the Ministry of Public Health
Russian Federation
Russian Federation
A. L. Gintsburg
Gamaleya Federal Research Centre for Microbiology and Immunology of the Ministry of Public Health; Sechenov the First Moscow Medical University of the Ministry of Public Health
Russian Federation
Russian Federation
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Review
For citations:
Zhukhovitsky V.G., Smirnova T.A., Shevlyagina N.V., Korzheva I.Yu., Didenko L.V., Gintsburg A.L. HELICOBACTER PYLORI BIOFILM IN VITRO AND IN VIVO. Experimental and Clinical Gastroenterology. 2017;(5):14-19. (In Russ.)
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