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THE POSSIBILITY OF USING INDIVIDUALLY SELECTED PROBIOTICS IN THE TREATMENT OF PATIENTS WITH METABOLIC SYNDROME AND INTESTINAL DYSBIOSIS

Abstract

Purpose: Evaluate the microbiological and clinical efficacy of the use of individually selected probiotics in patients with metabolic syndrome and intestinal dysbiosis. Materials and methods: The study involved 117 patients with metabolic syndrome (MS) and intestinal dysbiosis 1-2 degrees living in the therapeutic area. Formed three observation group. The main criteria for assigning patients to different groups of observations is the difference in adhesion, biocompatibility and the degree of antagonism of microorganisms isolated in the feces. To study the properties of probiotics in the effectiveness of the elimination of opportunistic pathogens, applied 5 probiotic food, probiotic 5 of medicines and dietary supplements containing bifidobacteria and lactobacilli. Microbiological Research, anthropometric and biochemical indicators of lipid profile was performed before and after treatment of patients with individually selected probiotics. Resuits: Patients in Group 1 after treatment with individually selected probiotics showed a significant decrease from baseline in body weight, BMI, fat mass, the content of triglycerides, total cholesterol and VLDL in the serum, accompanied by a decrease in atherogenic factor, as well as microbiological indicators faeces. Conclusions: Using the patients individually selected probiotics with high adhesion (4-5) and antagonism, not suppress indigenous lactobacilli and bifidobacteria in the background calorie diet helped correct microbiological parameters in the faeces of patients and biochemical indices of blood lipid profile, as well as more effective in reducing anthropometric indices and changing the composition of the body. Individual selection of probiotics reduces the risk of the use of those that can inhibit an indigenous microbiota of the patient’s own.

About the Authors

D. V. Kopchak
North-Western State Medical University named after I. I. Mechnikov
Russian Federation


E. A. Orichak
North-Western State Medical University named after I. I. Mechnikov
Russian Federation


V. V. Zakrevskii
North-Western State Medical University named after I. I. Mechnikov
Russian Federation


E. I. Tkachenko
North-Western State Medical University named after I. I. Mechnikov
Russian Federation


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Review

For citations:


Kopchak D.V., Orichak E.A., Zakrevskii V.V., Tkachenko E.I. THE POSSIBILITY OF USING INDIVIDUALLY SELECTED PROBIOTICS IN THE TREATMENT OF PATIENTS WITH METABOLIC SYNDROME AND INTESTINAL DYSBIOSIS. Experimental and Clinical Gastroenterology. 2016;(12):55-59. (In Russ.)

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