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Erosive and ulcerative lesions of the colon in a patient with HIV in the AIDS stage, complicated by phlegmon of the cecum

https://doi.org/10.31146/1682-8658-ecg-240-8-199-203

Abstract

The article presents a clinical case of a complicated course of erosive and ulcerative lesions of the colon with the development of phlegmon of the cecum in a patient with HIV infection in the AIDS stage. According to the results of a comprehensive examination, including histological examination, inflammatory bowel diseases and colitis caused by CMVI were excluded. The association with NSAID use was assessed as probable on the Naranjo scale. The outcome of the disease was a dynamic intestinal obstruction caused by phlegmonous colitis, which led to the death of the patient. The purpose of the publication was to draw the attention of specialists to the peculiarities of the course of colitis in HIV-infected patients, the difficulties of differential diagnosis, and risk factors for the development of colon phlegmon.

About the Authors

I. Yu. Kalinina
Omsk State Medical University; City Clinical Hospital for Emergency Medical Care
Russian Federation


G. R. Bikbavova
Omsk State Medical University; Omsk Region Regional Clinical Hospital
Russian Federation


S. G. Fominykh
Omsk State Medical University; City Clinical Hospital for Emergency Medical Care
Russian Federation


I. I. Kotov
Omsk State Medical University; City Clinical Hospital for Emergency Medical Care
Russian Federation


M. A. Paneva
Omsk State Medical University; Omsk Region Regional Clinical Hospital
Russian Federation


References

1. Tiralongo F., Di Pietro S., Milazzo D. et al. Acute Colonic Diverticulitis: CT Findings, Classifications, and a Proposal of a Structured Reporting Template. Diagnostics (Basel). 2023;13(24):3628. doi:10.3390/diagnostics13243628.

2. Cullen G., Vaughn B., Ahmed A. et al. Abdominal phlegmons in Crohn’s disease: outcomes following antitumor necrosis factor therapy. Inflamm Bowel Dis. 2012;18(4):691-696. doi:10.1002/ibd.21783.

3. Kimura K., Ichita C., Sumida C. et al. Phlegmonous Colitis after Cold Snare Polypectomy in an Immunosuppressed Patient: A Case Report. Case Rep Gastroenterol. 2024;18(1):110-116. doi:10.1159/000536487.

4. Timerbulatov V. M., Timerbulatov Sh.V., Sibaev V. M., Timerbulatov M. V. Diagnosis and treatment tactics of patients with purulent-septic complications of HIV infection. Bashkortostan Medical Journal. 2017;12(5):131-138. (In Russ.)@@ Тимербулатов В. М., Тимербулатов Ш. В., Сибаев В. М., Тимербулатов М. В. Вопросы диагностики и лечебной тактики при гнойно-септических осложнениях ВИЧ-инфекции. Медицинский вестник Башкортостана. 2017;12(5):131-138.

5. Huang W., Zhang Y. D., Wang P. et al. HIV infection increases the risk of inflammatory bowel disease: a systematic review and meta-analysis. BMC Infect Dis. 2024;24(1):1030. doi:10.1186/s12879-024-09964-z.

6. McEvoy L., Carr D. F., Pirmohamed M. Pharmacogenomics of NSAID-Induced Upper Gastrointestinal Toxicity. Front Pharmacol. 2021;12:684162. doi:10.3389/fphar.2021.684162.

7. Herlihy N., Feakins R. Gut inflammation induced by drugs: Can pathology help to differentiate from inflammatory bowel disease?. United European Gastroenterol J. 2022;10(5):451-464. doi: 10.1002/ueg2.12242.

8. Baniak N., Kanthan R. Cytomegalovirus Colitis: An Uncommon Mimicker of Common Colitides. Arch Pathol Lab Med. 2016;140(8):854-858. doi: 10.5858/arpa.2015-0176-RS.

9. Yerushalmy-Feler A., Padlipsky J., Cohen S. Diagnosis and Management of CMV Colitis. Curr Infect Dis Rep. 2019;21(2):5. doi:10.1007/s11908-019-0664-y.

10. Calafat M., Suria C., Mesonero F. et al. HIV Infection Is Associated With a Less Aggressive Phenotype of Inflammatory Bowel Disease: A Multicenter Study of the ENEIDA Registry. Am J Gastroenterol. 2025;120(2):431-439. doi: 10.14309/ajg.0000000000002965.

11. Vujkovic-Cvijin I., Somsouk M. HIV and the Gut Microbiota: Composition, Consequences, and Avenues for Amelioration. Curr HIV/AIDS Rep. 2019;16(3):204-213. doi: 10.1007/s11904-019-00441-w.

12. Dinh D. M., Volpe G. E., Duffalo C. et al.Intestinal microbiota, microbial translocation, and systemic inflammation in chronic HIV infection. J Infect Dis. 2015;211(1):19-27. doi: 10.1093/infdis/jiu409.

13. Qian G., Chen X., Liu G. et al. Exploring the etiology of colitis: insights from gut microbiota research. Gut Microbes. 2025;17(1):2512010. doi:10.1080/19490976.2025.2512010.

14. Bjarnason I., Scarpignato C., Holmgren E. et al. Mechanisms of Damage to the Gastrointestinal Tract From Nonsteroidal Anti-Inflammatory Drugs. Gastroenterology. 2018;154(3):500-514. doi: 10.1053/j.gastro.2017.10.049.

15. Ahmed A., Schmidt C., Brunner T. Extra-Adrenal Glucocorticoid Synthesis in the Intestinal Mucosa: Between Immune Homeostasis and Immune Escape. Front Immunol. 2019;10:1438. doi: 10.3389/fimmu.2019.01438.

16. Jazani N. H., Savoj J., Lustgarten M. et al. Impact of Gut Dysbiosis on Neurohormonal Pathways in Chronic Kidney Disease. Diseases. 2019;7(1):21. doi: 10.3390/diseases7010021.

17. Pahl M. V., Vaziri N. D. The Chronic Kidney Disease - Colonic Axis. Semin Dial. 2015;28(5):459-463. doi: 10.1111/sdi.12381.

18. Gorynya L. A., Mazurov V. I., Musatov V. B. Аnemia in patients with hiv and aids. pathogenesis and modern therapeutic strategy. Bulletin of the Saint Petersburg University. Medicine. 2014;(2):54-65. (In Russ.)@@ Горыня Л. А., Мазуров В. И., Мусатов В. Б. Анемия у ВИЧ-инфицированных пациентов. Патогенез и современная терапевтическая тактика. Вестник санкт-петербургского университета. Медицина. 2014;(2):54-65.

19. Silva J. M. Jr, dos Santos Sde S. Sepsis in AIDS patients: clinical, etiological and inflammatory characteristics. J Int AIDS Soc. 2013;16(1):17344. doi: 10.7448/IAS.16.1.17344.

20. Birkinshaw H., Friedrich C. M., Cole P. et al. Antidepressants for pain management in adults with chronic pain: a network meta-analysis. Cochrane Database Syst Rev. 2023;5(5): CD014682. doi: 10.1002/14651858.CD014682.pub2.


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For citations:


Kalinina I.Yu., Bikbavova G.R., Fominykh S.G., Kotov I.I., Paneva M.A. Erosive and ulcerative lesions of the colon in a patient with HIV in the AIDS stage, complicated by phlegmon of the cecum. Experimental and Clinical Gastroenterology. 2025;(8):199-203. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-240-8-199-203

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