Clinical and pathogenetic relationships between the state of the intestinal microbiota and neurological disorders
https://doi.org/10.31146/1682-8658-ecg-240-8-149-155
Abstract
The review article provides information on the mechanisms of functioning of the "gut-brain microbiota" axis, which supports bidirectional communication. The factors influencing this axis are noted, in particular diet, physical activity, and the administration of pre- and probiotic supplements. The results of studies on the effect of changes in the microbiota on the course of neurodegenerative diseases are presented, confirming that the onset and progression of neurodegenerative diseases are partially regulated by the intestinal microbiota. The results of both animal and human studies in Alzheimer's disease, Parkinson's disease, multiple sclerosis, and amyotrophic lateral sclerosis are presented, showing an altered composition of the intestinal microbiota and its metabolites. Measures to improve the state of the microbiota using transplantation of fecal microbiota and psychobiotics, presented as potential therapeutic agents for Alzheimer's disease, Parkinson's disease, multiple sclerosis, amyotrophic lateral sclerosis, depression and autism spectrum disorders, are considered.
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Review
For citations:
Akhmedov V.A. Clinical and pathogenetic relationships between the state of the intestinal microbiota and neurological disorders. Experimental and Clinical Gastroenterology. 2025;(8):149-155. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-240-8-149-155
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