THE MUTUAL DEPENDENCE OF GUT MICROBIOTA, IMMUNE STATUS IN CHILDREN WITH IRON-DEFICIENCY ANEMIA

Abstract

Purpose of the study: Study the condition of intestinal microbiota in infants and preschool children with IDA and to establish the relationship of severity of anemia depth dysbiotic and immune disorders. Material and methodsof research: The study involved 103 children aged 2 to 5 years (average age of 2,4±0,07 years) with IDA and 20 healthy children of the same age in the control group. Conducted bacteriological tests of feces, determine the concentration of cytokines (IL-1βand IL-1RA) in peripheral blood, blood test to determine the red blood cells, hemoglobin, color index, serum iron, hematocrit. Results of the study: In patients with IDA showed a significant reduction of bifidobacteria and lactobacteria (Р<0,01). Associate dysbiosis was detected in 47,5% of patients. In severe IDA disbiotic changes were more pronounced than in the mild and moderate severe disease. Status of cytokine profile in children with IDA and intestinal dysbiosis is characterized by oppression of nonspecific protection and specific immunity, inflammatory dissonanse. Conclusion. The relationship with the severity of anemia depth dysbiotic and immune disorders, this calls for an integrated approach to treatment.