Drug-induced liver injury associated with albendazole: a literature review and own clinical case of acute hepatitis C with liver failure in a 9-year-old child
https://doi.org/10.31146/1682-8658-ecg-245-1-84-90
Abstract
Brief information on drug-induced liver injury (criteria, classification) is presented, as well as a review of publications on albendazole-induced hepatitis (a total of 21 sources for the entire available period of Internet search with a total of 258 patients). Analysis of publications showed that the risk of hepatotoxicity when taking albendazole, although inferior to paracetamol, is quite expected with its wide prophylactic and therapeutic use. The author presents his own clinical observation of a 9-year-old child, who developed clinical hepatitis and acute liver failure a few days after independent administration of albendazole. Rapid positive dynamics with complete clinical and laboratory normalization during follow-up observation were achieved against the background of infusion and hepatoprotective therapy.
About the Authors
R. A. Gudkov
Ryazan State Medical University
Russian Federation
Russian Federation
A. V. Yamshchikova
Regional Children’s Clinical Hospital named after N.V. Dmitrieva
Russian Federation
Russian Federation
A. V. Dmitriev
Ryazan State Medical University
Russian Federation
Russian Federation
V. I. Petrova
Ryazan State Medical University
Russian Federation
Russian Federation
A. V. Gorelova
Ryazan State Medical University
Russian Federation
Russian Federation
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Review
For citations:
Gudkov R.A., Yamshchikova A.V., Dmitriev A.V., Petrova V.I., Gorelova A.V. Drug-induced liver injury associated with albendazole: a literature review and own clinical case of acute hepatitis C with liver failure in a 9-year-old child. Experimental and Clinical Gastroenterology. 2026;(1):84-90. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-245-1-84-90
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