Celiac disease in the aspect of comorbidity: facets and boundaries

Abstract

Celiac disease poses a serious diagnostic problem due to significant clinical polymorphism with a high frequency of atypical forms. The problem of comorbidity for celiac disease is relevant due to the possible involvement of almost all organs and systems in the pathological process. In this regard, the question arises of which symptoms are a manifestation of the disease, which are complications, and which symptoms are associated with comorbid conditions. The clinical polymorphism of celiac disease is obviously associated with damage to many organs in this disease. They all have a common starting point - an immunopathological process leading to malabsorption and secondary metabolic disorders, which are essentially a manifestation of the disease, but not complications, as is sometimes interpreted. A complication can be considered the oncological consequences of the disease, which develop after prolonged non-compliance of a gluten-free diet. The combination of celiac disease with associated diseases, primarily autoimmune diseases, should be considered as a manifestation of comorbidity.