THE FREQUENCY OF DYSPEPTIC DISORDERS FOLLOWING CHOLECYSTECTOMY PATIENTS ACCORDING TO THE 10-YEAR STUDY
Abstract
Aim: To evaluate gastrointestinal symptoms during 10 years after cholecystectomy in patients with symptomatic and asymptomatic gallstone disease and to identify predictors of them. Materials and Methods: The work is the part of a prospective long-term monitoring of patients with symptomatic (1) and asymptomatic (2) gallstone disease after cholecystectomy (CE). The study included 145 patients: 115 (80.7%) with initially symptomatic disease (1) and 30 (21.5%) asymptomatic (2) disease. Results: The frequency of heartburn increased from 15.9% to 63.7% during 10 years (p = 0.015) after CE especially in the group (1) (from 2.24% to 68.53% (p = 0.037). The frequency of "bitter taste in the mouth” raised from 46.9% before the CE to 69.02% after CE (p < 0.001). The frequency of diarrhea increased from 0.88% to 38.2% in both groups. (p = 0.046). Conclusion: The frequency of heartburn, "bitter taste in the mouth", diarrhea increased in patients after 10 years in patients with symptomatic and asymptomatic gallstone disease after CE. A common risk factors are presence symptomps at baseline and the presence of these symptoms at the first years after CE.
About the Authors
Yu. V. Makarova
Novosibirsk State Medical University, Russian Ministry of Health
Russian Federation
Russian Federation
N. V. Litvinova
Novosibirsk State Medical University, Russian Ministry of Health
Russian Federation
Russian Federation
M. F. Osipenko
Novosibirsk State Medical University, Russian Ministry of Health
Russian Federation
Russian Federation
N. B. Voloshina
Novosibirsk State Medical University, Russian Ministry of Health
Russian Federation
Russian Federation
Ya. A. Frolov
Novosibirsk State Medical University, Russian Ministry of Health
Russian Federation
Russian Federation
References
1. Минушкин О. Н. Синдром после холецистэктомии в практике терапевта и гастроэнтеролога. Лечащий врач, 2015, no. 2, с. 40-46.
2. Козлова И. В., Граушкина Е. В., Волков С. Клинико-функциональные и структурные гастродуоденальной зоны после холецистэктомии. Врач, 2010, no. 9, с. 72-76.
3. Wanjura V., Sandblom G. How Do Quality-of-Life and Gastrointestinal Symptoms Differ Between Post-cholecystectomy Patients and the Background Population, G. World J Surg, 2016 Jan., no. 40 (1), рр. 8-81.
4. Dong J. H., Ye S., Duan W. D., Ji W. B., Liang Y. R. Feasibility of liver graft procurement with donor gallbladder preservation in living donor liver transplantation. Hepatol Int, 2015 Oct., no. 9 (4), рр. 11-603.
5. Krums L. M., Parfenov A. I., Gubina A. V., Sil'vestrova SIu, et al. Cholagenic diarrhea is a type of postcholescystectomy syndrome. Ter Arkh, 2013, no. 85 (2), рр. 5-32.
6. Filip M., Saftoiu А, Popescu С., Gheonea D. I. et al. / Postcholecystectomy syndrome - an algorithmic approach. J. Gastrointestin. Liver Dis, 2009, no.18 (1), рр. 71-67.
7. Осипенко М. Ф., Волошина Н. Б., Литвинова Н. В. Последствия оперативного лечения желчнокаменной болезни. Практическая медицина, 2012, no. 3, рр. 38-43.
8. Niranjan B., Chumber S., Kriplani A. K. Symptomatic outcome after laparoscopic cholecystectomy. Trop Gastroenterol, 2000 Jul-Sep., no. 21 (3), рр. 8-144.
9. Литвинова Н. В., Осипенко М. Ф., Волошина Н. Б. Оценка качества жизни больных с желчнокаменной болезнью после холецистэктомии при симптомном и асимптомном течении заболевания. Медицина и образование в Сибири, 2009, no. 2, с. 6-10.
10. Lamberts M. P., Den Oudsten B. L., Keus F., De Vries J., et аl. Patient-reported outcomes of symptomatic cholelithiasis patients following cholecystectomy after at least 5 years of follow-up: a long-term prospective cohort study. Surg Endosc., 2014 Dec., no. 28 (12), рр. 50-3443.
11. Parmar A. K., Khandelwal R. G., Mathew M. J., Reddy P. K. Laparoscopic completion cholecystectomy: a retrospective study of 40 cases. Asian J Endosc Surg., 2013 May., no. 6 (2), рр. 9-96.
12. Костенко М. Б., Ливзан М. А. Механизмы развития синдрома раздраженного кишечника. Сибирский вестник гепатологии и гастроэнтерологии, 2000, no. 10, с. 32.
13. Мечетина Т. А. Синдром избыточного бактериального роста в тонкой кишке после холецистэктомии. Автореферат дисс… канд. мед. наук. - М., - 2011.
Review
For citations:
Makarova Yu.V., Litvinova N.V., Osipenko M.F., Voloshina N.B., Frolov Ya.A. THE FREQUENCY OF DYSPEPTIC DISORDERS FOLLOWING CHOLECYSTECTOMY PATIENTS ACCORDING TO THE 10-YEAR STUDY. Experimental and Clinical Gastroenterology. 2016;(9):48-53. (In Russ.)
Views:
181
Email this article 