State of immune status and immune correction in patients with chronic colostasis

Purpose of the study. Assessment of the immune status in patients with chronic colostasis and methods for its correction. Material and methods. An assessment of the severity of disorders in the immune system was carried out with a comparative study of indicators of both cellular and humoral immunity in the blood serum in 92 patients with various stages of chronic colostasis. The patients were divided by disease stage: 31 (33.7%) - in the compensation stage, 33 (35.9%) - in the subcompensation stage, and 28 (30.4%) - with decompensated chronic colonic stasis. Results. The results of a study of immunological parameters in patients with chronic colostasis indicate the presence of changes in the immune status. In patients with sub- and decompensated stages of colostasis, the most pronounced decrease in T-lymphocytes (CD3+) (from 0.89±0.18x109/l to 0.67±0.22x109/l), T-helper cells (CD4+) (from 0.53±0.7x109/l to 0.38±0.6x109/l), as well as (CD8+) (from 0.57±0.4x109/l to 0.45±0.5x109/l). These changes indicate the functional failure of cells of the immune system. There is also a change in the humoral immunity, expressed by increased functional activity of B-lymphocytes, which is manifested in an increase in the level of Ig A (from 5.71 ± 2.4 g/l to 6.42 ± 2.9 g/l) and Ig M (from 5.73±2.1 g/l to 6.36±2.7 g/l) at sub- and decompensated stages of chronic colostasis. An increase in CEC concentration was also noted (from 84.6±11.4% to 90.7±9.4%). In order to improve the immune status of 32 patients with chronic colostasis, the immunomodulator Timocin was included in the complex treatment regimen, which was used intramuscularly at a dose of 1.0 ml every day for 7-10 days. Against the background of immunocorrection, these patients showed normalization of all studied parameters, in contrast to patients who did not receive immunocorrective therapy. Conclusion. Thus, with chronic colostasis, a secondary deficiency of the immune system is observed, the severity of which depends on the duration and stage of colostasis. This deficiency is manifested by a violation of both cellular and humoral immunity, requiring the pathogenetic inclusion of immunocorrective therapy in the complex of rehabilitation measures, especially in the early postoperative period.

chronic colostasis, stages of colostasis, immunological imbalance, immune correction, thymocin

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